抗疟氨基喹啉对哺乳动物组织中核酸前体掺入的抑制作用。
Inhibition of precursor incorporation into nucleic acids of mammalian tissues by antimalarial aminoquinolines.
作者信息
Field R C, Gibson B R, Holbrook D J, McCall B M
出版信息
Br J Pharmacol. 1978 Feb;62(2):159-64. doi: 10.1111/j.1476-5381.1978.tb08440.x.
Abstract
1 Chloroquine, primaquine and ethidium inhibitied thymidine incorporation into deoxyribonucleic acid of rat tissues when administered concurrently with the labelled precursor. 2 Chloroquine and primaquine inhibited the incorporation of uridine and adenine, but not orotate, into various ribonucleic acid fractions of liver of rats and mice. These drugs had no effect on leucine incorporation into hepatic protein in rats or mice. 3 Although chloroquine and primaquine are active against different stages in the life cycle of the malarial parasites, the two aminoquinolines exert similar effects in rodent tissues.
摘要
- 当氯喹、伯氨喹和乙锭与标记前体同时给药时，它们会抑制胸苷掺入大鼠组织的脱氧核糖核酸中。2. 氯喹和伯氨喹抑制尿苷和腺嘌呤掺入大鼠和小鼠肝脏的各种核糖核酸组分中，但不抑制乳清酸掺入。这些药物对大鼠或小鼠肝脏中亮氨酸掺入蛋白质没有影响。3. 尽管氯喹和伯氨喹对疟原虫生命周期的不同阶段有活性，但这两种氨基喹啉在啮齿动物组织中发挥相似的作用。
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本文引用的文献
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The influence of antimalarial drugs on nucleic acid synthesis in Plasmodium gallinaceum and Plasmodium berghei.抗疟药物对鸡疟原虫和伯氏疟原虫核酸合成的影响。
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DNA biosynthesis in mitochondria. Differential inhibition of mitochondrial and nuclear DNA polymerases by the mutagenic dyes ethidium bromide and acriflavin.线粒体中的DNA生物合成。诱变染料溴化乙锭和吖啶黄素对线粒体和核DNA聚合酶的差异抑制作用。
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