一对嵌合双胞胎的血清学标志物和染色体变异

Serologic markers and chromosome variants in a pair of chimeric twins.

作者信息

Hansen H E, Eriksen B, Niebuhr E, Dabelsteen E

出版信息

Hum Hered. 1978;28(6):411-20. doi: 10.1159/000152992.

Abstract

A pair of chimeric twins, T.S. (male) and M.R. (female) first examined in 1970 are reinvestigated in order to determine if the proportions of admixture of red cells in their blood are unchanged, and if erythrocytes and leukocytes show the same percentage of admixture. T.S., M.R. and their family are investigated for HLA, serum types, and erythrocyte antigens and enzymes. A quantitative determination of 'foreign' cell populations in the blood of each twin is attempted for the systems ABO, and HLA, and for sex chromosomes in PHA stimulated lymphocytes. The results for the ABO system obtained by agglutination technique and by a double-layer immunofluorescence technique indicate that the population of M.R. erythrocytes in T.S. has decreased during the 7-year period, and is now below half the size found in 1970. Erythrocytes and leukocytes show the same percentage of admixture in both twins.

摘要

一对嵌合体双胞胎，T.S.（男）和M.R.（女）于1970年首次接受检查，现再次进行调查，以确定其血液中红细胞混合比例是否保持不变，以及红细胞和白细胞的混合百分比是否相同。对T.S.、M.R.及其家人进行了HLA、血清类型、红细胞抗原和酶的调查。尝试对每个双胞胎血液中的“外来”细胞群体进行定量测定，包括ABO系统、HLA系统以及PHA刺激淋巴细胞中的性染色体。通过凝集技术和双层免疫荧光技术获得的ABO系统结果表明，在7年期间，T.S.体内M.R.的红细胞数量减少，目前已低于1970年发现数量的一半。在这对双胞胎中，红细胞和白细胞的混合百分比相同。