Bogden J D, Thind I S, Kemp F W, Caterini H
J Lab Clin Med. 1978 Sep;92(3):455-62.
A study of the relationship between low birth weight and concentrations of six metals in maternal and cord plasma was conducted. Maternal and cord blood were collected at delivery. Cases and controls were matched for maternal age (+/- 3 yr), race, parity, socioeconomic status, and smoking habits and the sex of the neonate. Plasma concentrations of calcium, copper, magnesium, and zinc were determined by flame atomic absorption spectrophotometry; plasma chromium and iron concentrations were determined by flameless atomic absorption techniques. Mean maternal plasma concentrations were significantly lower in the low-birth-weight group than in the controls for iron (p = 0.012) and calcium (p = 0.007). Mean cord plasma concentrations were also significantly lower for calcium (p = 0.037). There were no statistically significant differences between the low- and normal-birth-weight groups for the maternal or cord chromium, copper, magnesium, and zinc concentrations or for the cord iron concentrations. It is probably true that many factors, acting additively or synergistically, can produce low birth weight, and that low birth weight acts only as a marker for a number of biologic insults. The results of this study suggest that nutrient metals may be one of these factors.
开展了一项关于低出生体重与母体和脐带血中六种金属浓度之间关系的研究。在分娩时采集母体和脐带血。病例组和对照组在产妇年龄（±3岁）、种族、胎次、社会经济地位、吸烟习惯以及新生儿性别方面进行了匹配。采用火焰原子吸收分光光度法测定血浆中钙、铜、镁和锌的浓度；采用无火焰原子吸收技术测定血浆中铬和铁的浓度。低出生体重组母体血浆中铁（p = 0.012）和钙（p = 0.007）的平均浓度显著低于对照组。脐带血血浆中钙的平均浓度也显著较低（p = 0.037）。低出生体重组与正常出生体重组在母体或脐带血中铬、铜、镁、锌的浓度以及脐带血中铁的浓度方面无统计学显著差异。很可能许多因素以相加或协同的方式起作用会导致低出生体重，而且低出生体重仅作为多种生物损伤的一个标志。本研究结果表明营养金属可能是这些因素之一。
