尼日利亚营养性共济失调性神经病患者的血浆氨基酸
Plasma amino-acids in the Nigerian nutritional ataxic neuropathy.
作者信息
Osuntokun B O, Durowoju J E, McFarlane H, Wilson J
出版信息
Br Med J. 1968 Sep 14;3(5619):647-9. doi: 10.1136/bmj.3.5619.647.
Abstract
Investigation of nine patients with tropical ataxic neuropathy showed an absence or diminution of sulphur-containing amino-acids-cysteine and methionine-and a variable concentration of most other essential amino-acids. The pattern was unlike that found in kwashiorkor. The levels of serum cholesterol and total protein were normal, and the serum vitamin B(12) levels were normal or high. Plasma thiocyanate concentration was high.All the patients gave a history of a monotonous diet of cassava derivatives. Cassava contains a cyanogenetic glycoside (linamarin) from which cyanide is released on hydrolysis. The excessive cyanide detoxication may be responsible for the low concentration of the sulphur-containing amino-acids.
摘要
对9例热带共济失调性神经病患者的调查显示，含硫氨基酸（半胱氨酸和蛋氨酸）缺乏或减少，而大多数其他必需氨基酸的浓度则各不相同。这种模式与夸希奥科病不同。血清胆固醇和总蛋白水平正常，血清维生素B12水平正常或偏高。血浆硫氰酸盐浓度较高。所有患者都有食用木薯衍生物单一饮食的病史。木薯含有一种生氰糖苷（亚麻苦苷），水解时会释放出氰化物。过量的氰化物解毒可能是含硫氨基酸浓度低的原因。
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