尼日利亚脊髓小脑性共济失调性神经病患者中羟钴胺素和核黄素的对照试验。
Controlled trial of hydroxocobalamin and riboflavine in Nigerian ataxic neuropathy.
作者信息
Osuntokun B O, Langman M J, Wilson J, Aladetoyinbo A
出版信息
J Neurol Neurosurg Psychiatry. 1970 Oct;33(5):663-6. doi: 10.1136/jnnp.33.5.663.
Abstract
The results are presented of a double-blind therapeutic trial of hydroxocobalamin and riboflavine in Nigerian patients suffering from a degenerative neuropathy. Although no benefit from either vitamin was demonstrated, this may reflect the inadequacy of the dosages used. The results are discussed in relation to the hypothesis that dietary cyanide and cyanogens are responsible, at least in part, for the occurrence of this disease in a malnourished population.
摘要
本文呈现了在患有退行性神经病变的尼日利亚患者中进行的一项关于羟钴胺素和核黄素的双盲治疗试验的结果。尽管未证明这两种维生素有任何益处，但这可能反映出所用剂量不足。本文结合以下假说对结果进行了讨论：饮食中的氰化物和含氰化合物至少在一定程度上是导致营养不良人群中出现这种疾病的原因。
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本文引用的文献
1
New concept of critical steps in course of chronic debilitating neurologic disease in evaluation of therapeutic response; a longitudinal study of multiple sclerosis by quantitative evaluation of neurologic involvement and disability.慢性衰弱性神经疾病病程中评估治疗反应关键步骤的新概念；通过对神经受累和残疾的定量评估对多发性硬化症的纵向研究
AMA Arch Neurol Psychiatry. 1951 Sep;66(3):253-71. doi: 10.1001/archneurpsyc.1951.02320090002001.
2
Chemical determination of vitamin B12. II. The quantitative isolation and colorimetric determination of millimicrogram quantities of cyanide.
Arch Biochem. 1951 Feb;30(2):372-81.
3
Multiple sclerosis. Treatment of acute exacerbations with corticotrophin (A.C.T.H.).多发性硬化症。用促肾上腺皮质激素（ACTH）治疗急性加重期。
Lancet. 1961 Nov 18;2(7212):1120-2. doi: 10.1016/s0140-6736(61)91030-3.
4
THERAPEUTIC EFFECT OF VITAMIN B COMPLEX ON AN ATAXIC SYNDROME IN WESTERN NIGERIA.复合维生素B对尼日利亚西部共济失调综合征的治疗效果
Trans R Soc Trop Med Hyg. 1964 Sep;58:432-6. doi: 10.1016/0035-9203(64)90091-4.
5
Leber's hereditary optic atrophy: some clinical and aetiological considerations.莱伯遗传性视神经萎缩：一些临床及病因学考量
Brain. 1963 Jun;86:347-62. doi: 10.1093/brain/86.2.347.
6
Relation of sub-acute combined degeneration of the cord to vitamin B 12 deficiency.脊髓亚急性联合变性与维生素B12缺乏的关系。
Nature. 1966 Nov 19;212(5064):787-9. doi: 10.1038/212787a0.
7
8
Leber's hereditary optic atrophy: a possible defect of cyanide metabolism.
Clin Sci. 1965 Dec;29(3):505-15.
9
Relationship of a degenerative tropical neuropathy to diet: report of a field survey.一种退行性热带神经病与饮食的关系：一项实地调查的报告。
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