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1
Controlled trial of hydroxocobalamin and riboflavine in Nigerian ataxic neuropathy.尼日利亚脊髓小脑性共济失调性神经病患者中羟钴胺素和核黄素的对照试验。
J Neurol Neurosurg Psychiatry. 1970 Oct;33(5):663-6. doi: 10.1136/jnnp.33.5.663.
2
Controlled trial of combinations of hydroxocobalamin-cystine and riboflavine-cystine, in Nigerian ataxic neuropathy.尼日利亚脊髓小脑性共济失调性神经病患者中，羟钴胺素-胱氨酸与核黄素-胱氨酸联合用药的对照试验。
J Neurol Neurosurg Psychiatry. 1974 Jan;37(1):102-4. doi: 10.1136/jnnp.37.1.102.
3
Biochemical studies in Tanzanian patients with ataxic tropical neuropathy.坦桑尼亚共济失调型热带神经病患者的生化研究
J Neurol Neurosurg Psychiatry. 1972 Feb;35(1):31-3. doi: 10.1136/jnnp.35.1.31.
4
Plasma amino-acids in the Nigerian nutritional ataxic neuropathy.尼日利亚营养性共济失调性神经病患者的血浆氨基酸
Br Med J. 1968 Sep 14;3(5619):647-9. doi: 10.1136/bmj.3.5619.647.
5
An ataxic neuropathy in Nigeria. A clinical, biochemical and electrophysiological study.尼日利亚的一种共济失调性神经病。一项临床、生化及电生理研究。
Brain. 1968 Jun;91(2):215-48. doi: 10.1093/brain/91.2.215.
6
Free-cyanide levels in tropical ataxic neuropathy.
Lancet. 1970 Aug 15;2(7668):372-3. doi: 10.1016/s0140-6736(70)92913-2.
7
Relationship of a degenerative tropical neuropathy to diet: report of a field survey.一种退行性热带神经病与饮食的关系：一项实地调查的报告。
Br Med J. 1969 Mar 1;1(5643):547-50. doi: 10.1136/bmj.1.5643.547.
8
Vitamin B nutrition in the Nigerian tropical ataxic neuropathy.尼日利亚热带性共济失调性神经病变中的维生素B营养状况
J Neurol Neurosurg Psychiatry. 1985 Feb;48(2):154-6. doi: 10.1136/jnnp.48.2.154.
9
Epidemiology of tropical nutritional neuropathy in Nigerians.尼日利亚人热带营养性神经病变的流行病学
Trans R Soc Trop Med Hyg. 1971;65(4):454-79. doi: 10.1016/0035-9203(71)90156-8.
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Incidence of endemic ataxic polyneuropathy and its relation to exposure to cyanide in a Nigerian community.尼日利亚某社区地方性共济失调性多神经病的发病率及其与氰化物暴露的关系。
J Neurol Neurosurg Psychiatry. 2003 Oct;74(10):1417-22. doi: 10.1136/jnnp.74.10.1417.

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Geospatial association of endemicity of ataxic polyneuropathy and highly cyanogenic cassava cultivars.地区性共济失调多发性神经病与高生氰木薯品种的地理关联。
Int J Health Geogr. 2013 Sep 14;12:41. doi: 10.1186/1476-072X-12-41.
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Neurological disorders associated with cassava diet: a review of putative etiological mechanisms.与木薯饮食相关的神经紊乱：疑似病因机制的综述。
Metab Brain Dis. 2011 Mar;26(1):79-85. doi: 10.1007/s11011-011-9237-y. Epub 2011 Feb 16.
3
Vitamin B for treating peripheral neuropathy.维生素B用于治疗周围神经病变。
Cochrane Database Syst Rev. 2008 Jul 16(3):CD004573. doi: 10.1002/14651858.CD004573.pub3.
4
Incidence of endemic ataxic polyneuropathy and its relation to exposure to cyanide in a Nigerian community.尼日利亚某社区地方性共济失调性多神经病的发病率及其与氰化物暴露的关系。
J Neurol Neurosurg Psychiatry. 2003 Oct;74(10):1417-22. doi: 10.1136/jnnp.74.10.1417.
5
Persistence of tropical ataxic neuropathy in a Nigerian community.尼日利亚某社区热带共济失调性神经病的持续性
J Neurol Neurosurg Psychiatry. 2000 Jul;69(1):96-101. doi: 10.1136/jnnp.69.1.96.
6
Controlled trial of combinations of hydroxocobalamin-cystine and riboflavine-cystine, in Nigerian ataxic neuropathy.尼日利亚脊髓小脑性共济失调性神经病患者中，羟钴胺素-胱氨酸与核黄素-胱氨酸联合用药的对照试验。
J Neurol Neurosurg Psychiatry. 1974 Jan;37(1):102-4. doi: 10.1136/jnnp.37.1.102.
7
Role of vegetarianism, smoking, and hydroxocobalamin in optic neuritis.素食主义、吸烟和羟钴胺在视神经炎中的作用。
Br Med J. 1972 Jul 29;3(5821):264-7. doi: 10.1136/bmj.3.5821.264.

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New concept of critical steps in course of chronic debilitating neurologic disease in evaluation of therapeutic response; a longitudinal study of multiple sclerosis by quantitative evaluation of neurologic involvement and disability.慢性衰弱性神经疾病病程中评估治疗反应关键步骤的新概念；通过对神经受累和残疾的定量评估对多发性硬化症的纵向研究
AMA Arch Neurol Psychiatry. 1951 Sep;66(3):253-71. doi: 10.1001/archneurpsyc.1951.02320090002001.
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Chemical determination of vitamin B12. II. The quantitative isolation and colorimetric determination of millimicrogram quantities of cyanide.
Arch Biochem. 1951 Feb;30(2):372-81.
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Multiple sclerosis. Treatment of acute exacerbations with corticotrophin (A.C.T.H.).多发性硬化症。用促肾上腺皮质激素（ACTH）治疗急性加重期。
Lancet. 1961 Nov 18;2(7212):1120-2. doi: 10.1016/s0140-6736(61)91030-3.
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THERAPEUTIC EFFECT OF VITAMIN B COMPLEX ON AN ATAXIC SYNDROME IN WESTERN NIGERIA.复合维生素B对尼日利亚西部共济失调综合征的治疗效果
Trans R Soc Trop Med Hyg. 1964 Sep;58:432-6. doi: 10.1016/0035-9203(64)90091-4.
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Leber's hereditary optic atrophy: some clinical and aetiological considerations.莱伯遗传性视神经萎缩：一些临床及病因学考量
Brain. 1963 Jun;86:347-62. doi: 10.1093/brain/86.2.347.
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Relation of sub-acute combined degeneration of the cord to vitamin B 12 deficiency.脊髓亚急性联合变性与维生素B12缺乏的关系。
Nature. 1966 Nov 19;212(5064):787-9. doi: 10.1038/212787a0.
7
Metabolic inter-relationships between cyanide, thiocyanate and vitamin B 12 in smokers and non-smokers.吸烟者与非吸烟者体内氰化物、硫氰酸盐和维生素B12之间的代谢相互关系。
Clin Sci. 1966 Aug;31(1):1-7.
8
Leber's hereditary optic atrophy: a possible defect of cyanide metabolism.
Clin Sci. 1965 Dec;29(3):505-15.
9
Relationship of a degenerative tropical neuropathy to diet: report of a field survey.一种退行性热带神经病与饮食的关系：一项实地调查的报告。
Br Med J. 1969 Mar 1;1(5643):547-50. doi: 10.1136/bmj.1.5643.547.
10
An ataxic neuropathy in Nigeria. A clinical, biochemical and electrophysiological study.尼日利亚的一种共济失调性神经病。一项临床、生化及电生理研究。
Brain. 1968 Jun;91(2):215-48. doi: 10.1093/brain/91.2.215.

尼日利亚脊髓小脑性共济失调性神经病患者中羟钴胺素和核黄素的对照试验。

Controlled trial of hydroxocobalamin and riboflavine in Nigerian ataxic neuropathy.

作者信息

Osuntokun B O, Langman M J, Wilson J, Aladetoyinbo A

出版信息

J Neurol Neurosurg Psychiatry. 1970 Oct;33(5):663-6. doi: 10.1136/jnnp.33.5.663.

DOI:10.1136/jnnp.33.5.663
PMID:4920799
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC493545/
Abstract

The results are presented of a double-blind therapeutic trial of hydroxocobalamin and riboflavine in Nigerian patients suffering from a degenerative neuropathy. Although no benefit from either vitamin was demonstrated, this may reflect the inadequacy of the dosages used. The results are discussed in relation to the hypothesis that dietary cyanide and cyanogens are responsible, at least in part, for the occurrence of this disease in a malnourished population.

摘要

本文呈现了在患有退行性神经病变的尼日利亚患者中进行的一项关于羟钴胺素和核黄素的双盲治疗试验的结果。尽管未证明这两种维生素有任何益处，但这可能反映出所用剂量不足。本文结合以下假说对结果进行了讨论：饮食中的氰化物和含氰化合物至少在一定程度上是导致营养不良人群中出现这种疾病的原因。