粗糙脉孢菌对外源和内源鸟氨酸的利用
Utilization of exogenous and endogenous ornithine by Neurospora crassa.
作者信息
Davis R H
出版信息
J Bacteriol. 1968 Aug;96(2):389-95. doi: 10.1128/jb.96.2.389-395.1968.
Abstract
Through the use of a mutant deficient in ornithine-delta-transaminase (OTA), it is shown that this enzyme normally has no obligate or even major biosynthetic role in Neurospora. The pathways of ornithine and proline synthesis proceed wholly independently of each other in OTA-less strains. It is probable that OTA functions as an enzyme of arginine catabolism. With mutants affected in OTA, ornithine transcarbamylase, and the synthesis of ornithine, it was demonstrated that exogenous and endogenous ornithine are utilized in different ways. Exogenous ornithine is destined mainly for catabolism, whereas endogenous ornithine is destined mainly for biosynthesis. It is suggested that this distinction depends upon differences in the intracellular location or origin of the two sources of ornithine.
摘要
通过使用鸟氨酸-δ-转氨酶（OTA）缺陷型突变体，研究表明该酶在粗糙脉孢菌中通常没有必需的甚至主要的生物合成作用。在无OTA菌株中，鸟氨酸和脯氨酸的合成途径完全相互独立进行。OTA可能作为精氨酸分解代谢的一种酶发挥作用。利用受OTA、鸟氨酸转氨甲酰酶和鸟氨酸合成影响的突变体，证明外源和内源鸟氨酸的利用方式不同。外源鸟氨酸主要用于分解代谢，而内源鸟氨酸主要用于生物合成。有人认为这种区别取决于两种鸟氨酸来源在细胞内位置或起源的差异。
相似文献
1
Utilization of exogenous and endogenous ornithine by Neurospora crassa.粗糙脉孢菌对外源和内源鸟氨酸的利用
J Bacteriol. 1968 Aug;96(2):389-95. doi: 10.1128/jb.96.2.389-395.1968.
2
Arginaseless Neurospora: genetics, physiology, and polyamine synthesis.无精氨酸脉孢菌：遗传学、生理学与多胺合成
J Bacteriol. 1970 May;102(2):299-305. doi: 10.1128/jb.102.2.299-305.1970.
3
Mutants of Neurospora crassa deficient in ornithine-delta-transmainase.缺乏鸟氨酸-δ-转氨酶的粗糙脉孢菌突变体。
J Bacteriol. 1968 Aug;96(2):383-8. doi: 10.1128/jb.96.2.383-388.1968.
4
Arginine catabolism in Neurospora: cycling of ornithine.脉孢菌中的精氨酸分解代谢：鸟氨酸循环
J Bacteriol. 1977 Apr;130(1):285-91. doi: 10.1128/jb.130.1.285-291.1977.
5
Regulation of arginase activity by intermediates of the arginine biosynthetic pathway in Neurospora crassa.粗糙脉孢菌中精氨酸生物合成途径中间体对精氨酸酶活性的调控。
J Bacteriol. 1972 Jun;110(3):870-7. doi: 10.1128/jb.110.3.870-877.1972.
6
Intracellular localization of ornithine and arginine pools in Neurospora.脉孢菌中鸟氨酸和精氨酸库的细胞内定位。
J Biol Chem. 1973 Aug 10;248(15):5409-13.
7
Arginine-specific carbamoyl phosphate metabolism in mitochondria of Neurospora crassa. Channeling and control by arginine.粗糙脉孢菌线粒体中精氨酸特异性氨甲酰磷酸代谢。精氨酸的通道化及调控。
J Biol Chem. 1987 May 25;262(15):7109-17.
8
Control of the ornithine cycle in Neurospora crassa by the mitochondrial membrane.粗糙脉孢菌中线粒体膜对鸟氨酸循环的调控。
J Bacteriol. 1983 Jun;154(3):1046-53. doi: 10.1128/jb.154.3.1046-1053.1983.
9
Compartmental behavior of ornithine in Neurospora crassa.鸟氨酸在粗糙脉孢菌中的区室化行为。
J Biol Chem. 1976 Jul 10;251(13):3948-55.
10
Effect of carbon source on enzymes and metabolites of arginine metabolism in Neurospora.碳源对粗糙脉孢菌精氨酸代谢中酶及代谢产物的影响。
J Bacteriol. 1980 Jan;141(1):205-12. doi: 10.1128/jb.141.1.205-212.1980.
引用本文的文献
1
Regulation of polyamine synthesis in relation to putrescine and spermidine pools in Neurospora crassa.粗糙脉孢菌中多胺合成与腐胺和亚精胺库的关系调控
J Bacteriol. 1981 Jan;145(1):14-20. doi: 10.1128/jb.145.1.14-20.1981.
2
Basic amino acids and inorganic polyphosphates in Neurospora crassa: independent regulation of vacuolar pools.粗糙脉孢菌中的碱性氨基酸和无机多磷酸盐：液泡池的独立调节
J Bacteriol. 1980 Jun;142(3):945-52. doi: 10.1128/jb.142.3.945-952.1980.
3
Isolation and characterization of Neurospora crassa mutants impaired in feedback control of ornithine synthesis.鸟氨酸合成反馈控制受损的粗糙脉孢菌突变体的分离与鉴定。
J Bacteriol. 1980 Mar;141(3):1305-11. doi: 10.1128/jb.141.3.1305-1311.1980.
4
Chromosomal loci of Neurospora crassa.粗糙脉孢菌的染色体位点。
Microbiol Rev. 1982 Dec;46(4):426-570. doi: 10.1128/mr.46.4.426-570.1982.
5
Mutants of Neurospora crassa deficient in ornithine-delta-transmainase.缺乏鸟氨酸-δ-转氨酶的粗糙脉孢菌突变体。
J Bacteriol. 1968 Aug;96(2):383-8. doi: 10.1128/jb.96.2.383-388.1968.
6
Arginaseless Neurospora: genetics, physiology, and polyamine synthesis.无精氨酸脉孢菌：遗传学、生理学与多胺合成
J Bacteriol. 1970 May;102(2):299-305. doi: 10.1128/jb.102.2.299-305.1970.
7
New markers and map sequences in Neurospora crassa, with a description of mapping by duplication coverage, and of multiple translocation stocks for testing linkage.粗糙脉孢菌中的新标记和图谱序列，以及通过重复覆盖进行图谱绘制和用于测试连锁的多个易位株系的描述。
Genetica. 1969;40(3):247-78. doi: 10.1007/BF01787357.
8
Comparison of RNA's transcribed in vivo from mitochondrial DNA of cytoplasmic and chromosomal respiratory deficient mutants.细胞质和染色体呼吸缺陷型突变体线粒体DNA在体内转录的RNA的比较。
Mol Gen Genet. 1969 Jul 3;104(3):264-81. doi: 10.1007/BF02539291.
9
Precursor pools and endogenous control of enzyme synthesis and activity in biosynthetic pathways.生物合成途径中酶合成与活性的前体库及内源性调控
Bacteriol Rev. 1974 Mar;38(1):1-28. doi: 10.1128/br.38.1.1-28.1974.
10
Cross-pathway regulation: histidine-mediated control of histidine, tryptophan, and arginine biosynthetic enzymes in Neurospora crassa.跨途径调控：粗糙脉孢菌中组氨酸介导的对组氨酸、色氨酸和精氨酸生物合成酶的控制
J Bacteriol. 1974 Sep;119(3):893-98. doi: 10.1128/jb.119.3.893-898.1974.
本文引用的文献
1
ON THE GLUTAMATE-PROLINE-ORNITHINE INTERRELATION IN NEUROSPORA CRASSA.粗糙脉孢菌中谷氨酸-脯氨酸-鸟氨酸的相互关系
Proc Natl Acad Sci U S A. 1954 Aug;40(8):688-94. doi: 10.1073/pnas.40.8.688.
2
Observations on the Behavior of Suppressors in Neurospora.对粗糙脉孢菌中抑制基因行为的观察
Proc Natl Acad Sci U S A. 1952 Mar;38(3):205-14. doi: 10.1073/pnas.38.3.205.
3
Amino acid biosynthesis in Torulopsis utilis and Neurospora crassa.产朊假丝酵母和粗糙脉孢菌中的氨基酸生物合成。
J Biol Chem. 1955 Mar;213(1):355-64.
4
POTASSIUM TRANSPORT IN NEUROSPORA. I. INTRACELLULAR SODIUM AND POTASSIUM CONCENTRATIONS, AND CATION REQUIREMENTS FOR GROWTH.粗糙脉孢菌中的钾转运。I. 细胞内钠和钾浓度以及生长所需的阳离子
Biochim Biophys Acta. 1964 Nov 29;88:578-92.
5
[BIOSYNTHESIS OF ARGININE IN YEAST. I. THE FATE OF N-ALPHA-ACETYLORNITHINE].[酵母中精氨酸的生物合成。I. N-α-乙酰鸟氨酸的去向]
Biochim Biophys Acta. 1963 Dec 13;78:606-16. doi: 10.1016/0006-3002(63)91026-6.
6
STRUCTURAL GENE FOR ORNITHINE TRANSCARBAMYLASE IN NEUROSPORA.脉孢菌中鸟氨酸转氨甲酰酶的结构基因。
Genetics. 1963 Nov;48(11):1551-8. doi: 10.1093/genetics/48.11.1551.
7
Consequences of a suppressor gene effective with pyrimidine and proline mutants of Neurospora.一种对粗糙脉孢菌嘧啶和脯氨酸突变体有效的抑制基因的后果。
Genetics. 1962 Mar;47(3):351-60. doi: 10.1093/genetics/47.3.351.
8
A mutant form of ornithine transcarbamylase found in a strain of Neurospora carrying a pyrimidine-proline suppressor gene.在携带嘧啶 - 脯氨酸抑制基因的粗糙脉孢菌菌株中发现的鸟氨酸转氨甲酰酶的一种突变形式。
Arch Biochem Biophys. 1962 Apr;97:185-91. doi: 10.1016/0003-9861(62)90063-2.
9
10
Photometric estimation of proline and ornithine.脯氨酸和鸟氨酸的光度测定
J Biol Chem. 1952 Nov;199(1):91-5.
Zotero 插件