跨途径调控：粗糙脉孢菌中组氨酸介导的对组氨酸、色氨酸和精氨酸生物合成酶的控制
Cross-pathway regulation: histidine-mediated control of histidine, tryptophan, and arginine biosynthetic enzymes in Neurospora crassa.
作者信息
Carsiotis M, Jones R F, Wesseling A C
出版信息
J Bacteriol. 1974 Sep;119(3):893-98. doi: 10.1128/jb.119.3.893-898.1974.
Abstract
In Neurospora crassa, histidine starvation of histidine mutants resulted in derepression of histidine, tryptophan, and arginine biosynthetic enzymes. The same tripartite derepression occurred in wild-type strain 74A when it was grown in medium supplemented with 3-amino-1,2,4-triazole, an inhibitor of histidine biosynthesis. Histidine-mediated derepression of tryptophan and arginine biosynthetic enzymes was not due to a lowered intracellular concentration of tryptophan or arginine, respectively. A discussion of possible mechanisms and of similar studies in prokaryotic and eukaryotic organisms is presented.
摘要
在粗糙脉孢菌中，组氨酸突变体的组氨酸饥饿导致组氨酸、色氨酸和精氨酸生物合成酶的去阻遏。当野生型菌株74A在添加了3-氨基-1,2,4-三唑（一种组氨酸生物合成抑制剂）的培养基中生长时，也会出现同样的三方去阻遏现象。组氨酸介导的色氨酸和精氨酸生物合成酶的去阻遏分别不是由于细胞内色氨酸或精氨酸浓度降低所致。本文还讨论了可能的机制以及原核生物和真核生物中的类似研究。
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