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锂对大鼠苯乙胺行为的影响可被单胺氧化酶A和B抑制剂抵消。

The effects of lithium on phenylethylamine behavior in rats are counteracted by monoamine oxidase A and B inhibitors.

作者信息

Smith D F

出版信息

Arch Int Pharmacodyn Ther. 1978 Jun;233(2):221-6.

PMID:567462
Abstract

Rats given a subcutaneous injection of beta-phenylethyl-amine (PEA) (30 or 60 mg/kg) showed stereotyped behavior and autonomic effects which were suppressed by LiCl. Inhibition of Type A MAO by clorgyline or Lilly 51641 (2 or 8 mg/kg) or of Type B MAO by l-deprenyl (2 or 8 mg/kg) counteracted the suppressant effects of LiCl on PEA-behavior. The findings suggest that both Type A MAO and Type B MAO play a role in the effects of LiCl on PEA-behavior.

摘要

皮下注射β-苯乙胺(PEA)(30或60毫克/千克)的大鼠表现出刻板行为和自主神经效应,这些效应可被氯化锂抑制。氯吉兰或礼来51641(2或8毫克/千克)对A型单胺氧化酶的抑制,或l-司来吉兰(2或8毫克/千克)对B型单胺氧化酶的抑制,抵消了氯化锂对PEA行为的抑制作用。这些发现表明,A型单胺氧化酶和B型单胺氧化酶在氯化锂对PEA行为的影响中均起作用。

相似文献

1
The effects of lithium on phenylethylamine behavior in rats are counteracted by monoamine oxidase A and B inhibitors.锂对大鼠苯乙胺行为的影响可被单胺氧化酶A和B抑制剂抵消。
Arch Int Pharmacodyn Ther. 1978 Jun;233(2):221-6.
2
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