Timoney P J, McArdle J F, O'Reilly P J, Ward J
Equine Vet J. 1978 Jul;10(3):148-52. doi: 10.1111/j.2042-3306.1978.tb02244.x.
Contagious equine metritis 1977 was reproduced in pony mares using cultures of the Gram-negative coccobacillus aetiologically associated with the disease. Variability in clinical response was observed in the first of 2 experiments, with the presence of semen, either alone or in an extender, appearing to potentiate the pathogenicity of the challenge strain of the organism. The experimental disease was characterised by a variable degree of vaginal discharge and concomitant inflammatory changes involving the vervix and vagina. Although all of the affected mares recovered spontaneously, a high percentage continued to harbour the Gram-negative coccobacillus in their genital tracts for variable periods after challenge. Shedding of the organism was either relatively constant or intermittent and was not solely related to the oestrous period. Cytological examination of smears of cervical and urethral swabs was of diagnostic value only during the clinical phase of the infection. There was evidence that reinfection of mares could occur after an interval of 2 weeks.
1977年，通过使用与该病病因相关的革兰氏阴性球杆菌培养物，在小母马中再现了传染性马子宫内膜炎。在2个实验中的第一个实验中观察到临床反应存在差异，精液单独存在或与稀释剂一起存在时，似乎会增强该生物体攻击菌株的致病性。实验性疾病的特征是阴道分泌物程度不一，并伴有涉及子宫颈和阴道的炎症变化。虽然所有受影响的母马都自发康复，但很大比例的母马在受到攻击后的不同时期，其生殖道中仍持续携带革兰氏阴性球杆菌。该生物体的排出相对稳定或断断续续，且不仅仅与发情期有关。仅在感染的临床阶段，对子宫颈和尿道拭子涂片进行细胞学检查才有诊断价值。有证据表明，母马在间隔2周后可能会再次感染。
