使用脑内注射致热原的方法对小鼠体内的解热药物进行测定。
The assay of anti-pyretic drugs in mice, using intracerebral injection of pyretogenins.
作者信息
Cashin C H, Heading C E
出版信息
Br J Pharmacol. 1968 Sep;34(1):148-58.
Abstract
- A simple, cheap, and reliable method is described for the screening of new compounds for anti-pyretic activity. It involves the intracerebral injection of a suitable pyretogenin in conscious mice.2. The pyretic response is related to the logarithm of the dose in a substantially linear manner when "E" Pyrogen is used.3. A selection of established anti-pyretic drugs were effective in oral doses approaching those used clinically, which shows that the method is unusually sensitive.4. The response to intracerebral pyretogenin is not unduly influenced by drugs known to cause hypothermia.5. It is suggested that "E" Pyrogen injected intracerebrally has a direct effect on the central nervous system, rather than an indirect action through release of endogenous pyrogen.
摘要
描述了一种用于筛选具有解热活性新化合物的简单、廉价且可靠的方法。该方法包括向清醒小鼠脑内注射合适的致热原。
使用“E”热原时，发热反应与剂量的对数呈基本线性关系。
选用的几种已确立的解热药物在接近临床使用剂量的口服给药时有效，这表明该方法异常灵敏。
已知引起体温过低的药物对脑内致热原的反应影响不大。
有人提出，脑内注射的“E”热原对中枢神经系统有直接作用，而非通过释放内源性热原产生间接作用。
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