Pakstis A J, Polesky H F, Scarr S, Katz S H
Hum Genet. 1978 Aug 31;43(2):159-77. doi: 10.1007/BF00293593.
Maximum likelihood estimates of gene frequencies and their standard errors are presented for 21 blood group and serum protein polymorphisms. The observed frequencies for certain high and low frequency antigens also are reported. The data come from a sample of 399 same-sex twin pairs and two sets of triplets from the Greater Philadelphia urban region encompassing roughly five counties in southeastern Pennsylvania and three counties of southern New Jersey. Analyses are carried out separately for the four subgroups created by subdividing the sample by race and co-twin. Total sample estimates are also calculated within the two socially defined racial groups. The gene frequency estimates generally appear to be consistent with previously reported data for U.S. urban populations. The frequency of the Fy allele in the Duffy system, however, seems to be the highest value thus far published for a white population. The white sample Fy allele very well may be a heterogeneous class in which only a very small fraction is comparable to the Fy allele common in the black sample.
本文给出了21种血型和血清蛋白多态性的基因频率最大似然估计值及其标准误差。还报告了某些高频和低频抗原的观察频率。数据来自大费城城区的399对同性双胞胎样本以及两组三胞胎，该城区大致涵盖宾夕法尼亚州东南部的五个县和新泽西州南部的三个县。按种族和同卵双胞胎对样本进行细分，分别对由此产生的四个亚组进行分析。还在两个社会定义的种族群体中计算了总样本估计值。基因频率估计值总体上似乎与之前报道的美国城市人口数据一致。然而，达菲系统中Fy等位基因的频率似乎是迄今为止公布的白人种群中的最高值。白人样本中的Fy等位基因很可能是一个异质类别，其中只有极小一部分与黑人样本中常见的Fy等位基因具有可比性。
