Slutsky A S, Goldstein R G, Rebuck A S
Br Heart J. 1979 Dec;42(6):709-14. doi: 10.1136/hrt.42.6.709.
The effects of progressive isocapnic hypoxia on the systolic time intervals were studied in 10 healthy human subjects. We induced hypoxia by a rebreathing method and monitored the arterial oxygen saturation continuously and non-invasively by means of an ear oximeter. Arterial oxygen saturation (SaO2) was allowed to fall to a level of 75 per cent and was then held constant for five minutes. As SaO2 fell, heart rate increased linearly, with a mean increase of 0.83 beats/min per one per cent fall in SaO2. The pre-ejection phase index decreased from a mean of 127.2 ms at full oxygen saturation to 120.1 ms at steady-state hypoxia levels, while the ratio of the pre-ejection phase to left ventricular ejection time decreased from a mean of 0.330 to 0.301. The left ventricular ejection time index increased from 417.4 ms to 429.3 ms, while no statistically significant difference was found in the length of electromechanical systole.
在10名健康受试者中研究了进行性等碳酸血症性低氧对收缩期时间间期的影响。我们采用再呼吸法诱导低氧，并通过耳部血氧计连续无创监测动脉血氧饱和度。动脉血氧饱和度（SaO2）降至75%的水平，然后保持5分钟恒定。随着SaO2下降，心率呈线性增加，SaO2每下降1%，平均增加0.83次/分钟。射血前期指数从完全氧饱和度时的平均127.2毫秒降至稳态低氧水平时的120.1毫秒，而射血前期与左心室射血时间的比值从平均0.330降至0.301。左心室射血时间指数从417.4毫秒增加到429.3毫秒，而机电收缩期长度未发现统计学上的显著差异。
