自身免疫性溶血性贫血与甲芬那酸治疗
Autoimmune haemolytic anaemia and mefenamic acid therapy.
作者信息
Scott G L, Myles A B, Bacon P A
出版信息
Br Med J. 1968 Aug 31;3(5617):534-5. doi: 10.1136/bmj.3.5617.534.
Abstract
Three patients developed autoimmune haemolytic anaemia while being treated with mefenamic acid. In each case the autoimmune haemolytic anaemia was of the warm antibody gammaG type, and the antibodies had some rhesus specificity. All three patients recovered when the drug was withdrawn.Attempts to inhibit or enhance the activity of the antibody in vitro were unsuccessful.Direct antihuman globulin tests were made in.the red cells of 36 patients receiving long-term mefenamic acid therapy, but only one was found to be transitorily positive.
摘要
三名患者在服用甲芬那酸治疗期间发生了自身免疫性溶血性贫血。在每例病例中，自身免疫性溶血性贫血均为温抗体γG型，且抗体具有一些恒河猴血型特异性。当停用该药物后，所有三名患者均康复。在体外抑制或增强抗体活性的尝试均未成功。对36名接受长期甲芬那酸治疗的患者的红细胞进行了直接抗人球蛋白试验，但仅发现1例呈短暂阳性。
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Autoimmune haemolytic anaemia and mefenamic acid therapy.自身免疫性溶血性贫血与甲芬那酸治疗
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