同步化的牛细小病毒感染细胞中细胞DNA聚合酶的水平
Levels of cellular DNA polymerases in synchronized bovine paravovirus-infected cells.
作者信息
Pritchard C, Bates R C, Stout E R
出版信息
J Virol. 1978 Jul;27(1):258-61.
Abstract
Infection of synchronized bovine fetal spleen cells with bovine parvovirus results in changes in the levels and patterns of DNA polymerases alpha and gamma during the cell cycle. The pattern of DNA polymerase alpha activity closely paralled viral DNA synthesis and the production of progeny virus, and levels, of this enzyme were threefold greater than in mock-infected cells during the period of maximal viral DNA synthesis. DNA polymerase gamma activity remained slightly elevated during viral DNA replication. Levels and patterns of DNA polymerase beta were similar in mock- and virus-infected cells.
摘要
用牛细小病毒感染同步化的牛胎儿脾细胞，会导致细胞周期中DNA聚合酶α和γ的水平及模式发生变化。DNA聚合酶α活性模式与病毒DNA合成以及子代病毒的产生密切平行，在病毒DNA合成达到最大值的时期，这种酶的水平比 mock 感染细胞中的高两倍。在病毒DNA复制过程中，DNA聚合酶γ活性仍略有升高。mock 感染细胞和病毒感染细胞中DNA聚合酶β的水平及模式相似。
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