肾小球滤过率对大鼠肾脏中对氨基马尿酸（PAH）分泌率的影响。PAH摄取对肾滤过分数的依赖性。
Influence of glomerular filtration rate on renal PAH secretion rate in the rat kidney. Dependency of PAH extraction on renal filtration fraction.
作者信息
Häberle D A, Ruhland G, Lausser A, Moore L, Neiss A
出版信息
Pflugers Arch. 1978 Jul 18;375(2):131-9. doi: 10.1007/BF00584235.
PAH secretion (TPAH) was studied in rats at spontaneously occurring glomerular filtration rate (GFR). At saturated transport, TPAH was found to be correlated to GFR. This relationship was also observed at unsaturated transport where TPAH depends upon the PAH concentration in arterial plasma. However, no significant correlation between TPAH and renal PAH load or renal plasma flow rate was found when the effects of GFR were removed by partial correlation analysis. A dependency of TPAH on GFR explains the correlations found between filtration fraction (FF) and renal PAH extraction (EPAH) or renal tubular PAH extraction fraction (EPAH--FFPAH). Thus, even at low PAH concentration in a. plasma, renal PAH extraction may only be assumed to be constant if the filtration fraction is constant.
在大鼠自然发生的肾小球滤过率（GFR）条件下研究了对氨基马尿酸（PAH）分泌（TPAH）。在饱和转运时，发现TPAH与GFR相关。在不饱和转运时也观察到这种关系，此时TPAH取决于动脉血浆中的PAH浓度。然而，当通过偏相关分析消除GFR的影响时，未发现TPAH与肾PAH负荷或肾血浆流速之间存在显著相关性。TPAH对GFR的依赖性解释了滤过分数（FF）与肾PAH清除率（EPAH）或肾小管PAH清除分数（EPAH - FFPAH）之间的相关性。因此，即使血浆中PAH浓度较低，只有当滤过分数恒定时，才能假定肾PAH清除率是恒定的。
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