路氏锥虫动基体的精细结构与复制
Fine structure and replication of the kinetoplast of Trypanosoma lewisi.
作者信息
Burton P R, Dusanic D G
出版信息
J Cell Biol. 1968 Nov;39(2):318-31. doi: 10.1083/jcb.39.2.318.
Abstract
The kinetoplastic DNA of Trypanosoma lewisi is described as a filamentous body lying within a mitochondrion, with the filaments oriented parallel to the long axis of the cell. The manner of fixation, the replicative state, and perhaps the physiological state of the cell, may result in slight morphological differences among such bodies. The kinetoplastic DNA replicates to form "left" and "right" rather than "upper" and "lower" members, and both the kinetoplast and nucleus incorporate radiothymidine as shown by radioautography. Radioautographic analyses suggest a random incorporation of radiothymidine by kinetoplasts. Silver grains were occasionally observed over centriolar elements. Finally, the observations are discussed with respect to the sequential replication of the aforementioned organelles by T. lewisi.
摘要
路氏锥虫的动质体DNA被描述为位于线粒体内的丝状结构，其细丝与细胞的长轴平行排列。固定方式、复制状态以及细胞的生理状态，可能导致这些结构之间存在细微的形态差异。动质体DNA复制形成“左”和“右”成员，而非“上”和“下”成员，并且如放射自显影所示，动质体和细胞核都能掺入放射性胸腺嘧啶核苷。放射自显影分析表明，动质体随机掺入放射性胸腺嘧啶核苷。在中心粒成分上偶尔能观察到银颗粒。最后，针对路氏锥虫上述细胞器的顺序复制对这些观察结果进行了讨论。
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