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[抗球蛋白对小鼠胚胎成纤维细胞中纤维状成分分布的影响]

[Effect of antibulins on the distribution of fibrillar elements in mouse embryonal fibroblasts].

作者信息

Svitkina T M

出版信息

Tsitologiia. 1978 Jul;20(7):736-41.

PMID:567864
Abstract

Effects of colcemid, colchicine and vinblastine on distribution of fibrillar elements (microtubules, microfilaments and 100 A filaments) in mouse embryo fibroblasts were studied by the transmission electron microscopy and by additional treatment of cells with cytochalasin B. All the fibrillar components under routine conditions were seen to form a system of elements with a radial distribution. After antitubulin treatment, the radial system was seen tranformed into a circular one, which consisted mainly of microfilament bundles apparently connecting cell peripheral attachment sites with each other.

摘要

通过透射电子显微镜以及用细胞松弛素B对细胞进行额外处理,研究了秋水仙酰胺、秋水仙碱和长春花碱对小鼠胚胎成纤维细胞中纤维状成分(微管、微丝和100埃细丝)分布的影响。在常规条件下,所有纤维状成分都形成了一个呈放射状分布的成分系统。抗微管蛋白处理后,放射状系统转变为环状系统,该环状系统主要由明显相互连接细胞周边附着位点的微丝束组成。

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