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The disposition of formaldehyde and formate arising from drug N-demethylations dependent on cytochrome P-450 in hepatocytes and in perfused rat liver.

作者信息

Waydhas C, Weigl K, Sies H

出版信息

Eur J Biochem. 1978 Aug 15;89(1):143-50. doi: 10.1111/j.1432-1033.1978.tb20906.x.

DOI:10.1111/j.1432-1033.1978.tb20906.x
PMID:568065
Abstract
摘要

相似文献

1
The disposition of formaldehyde and formate arising from drug N-demethylations dependent on cytochrome P-450 in hepatocytes and in perfused rat liver.肝细胞和灌注大鼠肝脏中依赖细胞色素P-450的药物N-去甲基化产生的甲醛和甲酸的处置情况。
Eur J Biochem. 1978 Aug 15;89(1):143-50. doi: 10.1111/j.1432-1033.1978.tb20906.x.
2
Detoxification reactions in isolated hepatocytes. Role of glutathione peroxidase, catalase, and formaldehyde dehydrogenase in reactions relating to N-demethylation by the cytochrome P-450 system.
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3
Mechanism of the nucleotide pyrophosphatase induced distortion of stoichiometry of TPNH utilization and product formation by hepatic cytochrome P-450 linked N-demethylase systems.
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4
Ethanol and drug metabolism in mouse liver microsomes subsequent to lipid peroxidation-induced destruction of cytochrome P-450.脂质过氧化诱导细胞色素P-450破坏后小鼠肝微粒体中的乙醇和药物代谢
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5
Production of hydroxyl radicals and their role in the oxidation of ethanol by a reconstituted microsomal system containing cytochrome P-450 purified from phenobarbital-treated rats.由含有从苯巴比妥处理过的大鼠中纯化的细胞色素P-450的重组微粒体系统产生羟自由基及其在乙醇氧化中的作用。
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6
Pyridine nucleotide involvement in rat hepatic microsomal drug metabolism--IV. Inhibition of aminopyrine and ethylmorphine-N-demethylases by 2.6-dihydroxy-acetophenone.
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7
Effect of ethanol and metabolic substrates on the oxidation of aminopyrine, formaldehyde and formate by isolated hepatocytes.乙醇和代谢底物对分离的肝细胞氧化氨基比林、甲醛和甲酸的影响。
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8
Effects of 6-aminochrysene on liver microsomal enzyme activity.6-氨基 Chrysene 对肝微粒体酶活性的影响。
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9
Suppression of hepatic DMN demethylase activity by nitrososarcosine and other nitrosamines.亚硝基肌氨酸和其他亚硝胺对肝脏DMN脱甲基酶活性的抑制作用。
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Xenobiotica. 1971 Jul-Oct;1(4):325-6. doi: 10.3109/00498257109041496.

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J Clin Invest. 1994 Dec;94(6):2426-34. doi: 10.1172/JCI117610.
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Involvement of glutathione reductase in selenite metabolism and toxicity, studied in isolated rat hepatocytes.谷胱甘肽还原酶在亚硒酸盐代谢及毒性中的作用，以分离的大鼠肝细胞为研究对象。
Arch Toxicol. 1982 Jul;50(2):113-23. doi: 10.1007/BF00373393.
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Report of the Federal Panel on Formaldehyde.联邦甲醛问题小组报告。
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Hepatic calcium efflux during cytochrome P-450-dependent drug oxidations at the endoplasmic reticulum in intact liver.完整肝脏内质网中细胞色素P-450依赖的药物氧化过程中的肝脏钙外流。
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3358-62. doi: 10.1073/pnas.78.6.3358.
10
Interpretation of CO2 exhalation rate data from demethylation of aminopyrine and its metabolite monomethylaminoantipyrine.从氨基比林及其代谢产物单甲基氨基安替比林的去甲基化解读二氧化碳呼出率数据。
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