Sprague G L, Craigmill A L
Pharmacol Biochem Behav. 1978 Jul;9(1):11-5. doi: 10.1016/0091-3057(78)90005-9.
The effects of delta9-tetrahydrocannabinol (THC) and nabilone, a synthetic cannabinoid, upon handling-induced convulsions and responsiveness to electric foot shock were examined during abstinence in ethanol-dependent mice. The severity of handling-induced convulsions was apparently increased by THC (10-40 mg/kg) and nabilone (2.5-10 mg/kg) but both drugs elicited similar convulsions in normal mice never exposed to ethanol. Enhanced responsiveness to electric foot shock, evident during abstinence, was suppressed by THC (10-40 MG/KG). The effects of ethanol upon the two abstinence signs were determined for comparative purposes. Ethanol (0.5-4 g/kg) reduced the severity of handling-induced convulsions and suppressed the increased responsiveness to electric foot shock. These results indicate that THC and nabilone have similar actions upon two abstinence signs in ethanol-dependent mice, and although one sign (responsiveness to electric foot shock) was clearly alleviated, another (handling-induced convulsions) was not.
在乙醇依赖小鼠戒断期间，研究了Δ⁹-四氢大麻酚（THC）和合成大麻素纳布隆对处理诱导的惊厥以及对足部电击反应性的影响。THC（10 - 40毫克/千克）和纳布隆（2.5 - 10毫克/千克）明显增加了处理诱导惊厥的严重程度，但这两种药物在从未接触过乙醇的正常小鼠中引发的惊厥相似。在戒断期间明显增强的对足部电击的反应性，被THC（10 - 40毫克/千克）抑制。为了进行比较，确定了乙醇对这两种戒断体征的影响。乙醇（0.5 - 4克/千克）降低了处理诱导惊厥的严重程度，并抑制了对足部电击增加的反应性。这些结果表明，THC和纳布隆对乙醇依赖小鼠的两种戒断体征有相似作用，并且虽然一种体征（对足部电击的反应性）明显减轻，但另一种（处理诱导的惊厥）没有。
