Bhargava H N
Pharmacol Biochem Behav. 1978 Jan;8(1):7-11. doi: 10.1016/0091-3057(78)90115-6.
The effects of a single intraperitoneal injection (10 mg/kg) of delta9-tetrahydrocannabinol, delta8-tetrahydrocannabinol and 11-hydroxy-delta8-tetrahydrocannabinol on abstinence syndrome were investigated in mice rendered dependent on morphine by pellet implantation. In morphine dependent mice from which the pellets had been removed, delta9-tetrahydrocannabinol inhibited the naloxone-precipitated jumping response as evidenced by an increase in the ED50 of naloxone. This inhibition was evident for 24 hr, the most pronounced effect being produced between two to four hr after delta9-tetrahydrocannabinol administration. Withdrawal defecation was also inhibited for two hours. Similarly, in mice from which pellets were not removed, delta9-tetrahydrocannabinol suppressed the jumping response; however, the intensity of effect was less than when the pellets were removed. delta8-tetrahydrocannabinol and 11-hydroxy-delta8-tetrahydrocannabinol were not effective in suppressing morphine abstinence syndrome two hr following their administration. The suppression of jumping response was specific, since, the vertical jumping behavior induced by coadministration of amphetamine and l-dopa was not affected by cannabinoids. These results demonstrate that single injection of delta9-tetrahydrocannabinol is effective in controlling morphine abstinence syndrome for 24 hr, and that the drugs related to cannabinoids may show promise in narcotic detoxification.
通过植入药 pellet 使小鼠对吗啡产生依赖性后，研究了单次腹腔注射（10毫克/千克）的δ9-四氢大麻酚、δ8-四氢大麻酚和11-羟基-δ8-四氢大麻酚对戒断综合征的影响。在已取出药 pellet 的吗啡依赖性小鼠中，δ9-四氢大麻酚抑制了纳洛酮诱发的跳跃反应，纳洛酮的半数有效量（ED50）增加即证明了这一点。这种抑制作用在24小时内都很明显，给药后两到四小时产生的效果最为显著。排便戒断也被抑制了两个小时。同样，在未取出药 pellet 的小鼠中，δ9-四氢大麻酚也抑制了跳跃反应；然而，其效果强度小于取出药 pellet 的情况。δ8-四氢大麻酚和11-羟基-δ8-四氢大麻酚在给药两小时后对抑制吗啡戒断综合征无效。跳跃反应的抑制是特异性的，因为同时给予苯丙胺和左旋多巴所诱发的垂直跳跃行为不受大麻素影响。这些结果表明，单次注射δ9-四氢大麻酚在24小时内有效控制吗啡戒断综合征，并且与大麻素相关的药物在戒毒方面可能具有前景。
