药物的整体转归：丙咪嗪治疗大鼠后其分布、排泄动力学及14种代谢产物的形成 - Suppr

Suppr

超能文献

The total fate of a drug: kinetics of distribution, excretion, and formation of 14 metabolites in rats treated with imipramine.

作者信息

Bickel M H, Weder H J

出版信息

Arch Int Pharmacodyn Ther. 1968 Jun;173(2):433-63.

PMID:5684271

Abstract

摘要

相似文献

The total fate of a drug: kinetics of distribution, excretion, and formation of 14 metabolites in rats treated with imipramine.药物的整体转归：丙咪嗪治疗大鼠后其分布、排泄动力学及14种代谢产物的形成

Arch Int Pharmacodyn Ther. 1968 Jun;173(2):433-63.

[Metabolic site of imipramine in the rat].[丙咪嗪在大鼠体内的代谢部位]

Arzneimittelforschung. 1970 Nov;20(11):1708-11.

Biotransformation and biliary excretion of imipramine in rats under various experimental conditions.

Arch Int Pharmacodyn Ther. 1975 Aug;216(2):315-27.

The metabolism and excretion of [14C]imipramine in an experimental hepatitis.实验性肝炎中[14C]丙咪嗪的代谢与排泄

Xenobiotica. 1984 Jun;14(6):491-9. doi: 10.3109/00498258409151436.

Pharmacokinetics of imipramine and its major metabolites in pregnant rats and their fetuses following a single dose.

Drug Metab Dispos. 1985 Jul-Aug;13(4):438-42.

Metabolism of 14C-imipramine. I. Excretion in the rat and in man.14C-丙咪嗪的代谢。I. 在大鼠和人体中的排泄

Psychopharmacologia. 1968;12(4):263-77. doi: 10.1007/BF00401406.

Effect of pregnenolone-16 alpha-carbonitrile on the biliary and urinary excretion of imipramine and some of its metabolites in rats.孕烯醇酮-16α-腈对大鼠体内丙咪嗪及其某些代谢产物胆汁和尿液排泄的影响。

Arzneimittelforschung. 1982;32(10):1298-301.

Effect of phenobarbitone on the distribution and elimination of imipramine in rats.苯巴比妥对大鼠体内丙咪嗪分布和消除的影响。

J Pharm Pharmacol. 1985 Oct;37(10):735-8. doi: 10.1111/j.2042-7158.1985.tb04955.x.

Mirex-induced impairment of hepatobiliary function. Suppressed biliary excretion of imipramine and sulfobromophthalein.

Drug Metab Dispos. 1977 Jan-Feb;5(1):56-62.

Imipramine metabolism: pH-dependent distribution and urinary excretion.丙咪嗪代谢：pH依赖性分布与尿排泄

Clin Pharmacol Ther. 1971 Mar-Apr;12(2):239-44. doi: 10.1002/cpt1971122part1239.

引用本文的文献

Cerebral pharmacokinetics of imipramine in rats after single and multiple dosages.单次及多次给药后大鼠体内丙咪嗪的脑药代动力学

Naunyn Schmiedebergs Arch Pharmacol. 1981 Nov;317(3):209-13. doi: 10.1007/BF00503818.

Different pharmacokinetic and pharmacological effects following acute and chronic treatment with imipramine.丙咪嗪急性和慢性治疗后的不同药代动力学和药理作用。

J Neural Transm. 1982;54(3-4):219-28. doi: 10.1007/BF01254931.

Relationships between brain concentrations of desipramine and paradoxical sleep inhibition in the rat.

J Neural Transm. 1983;56(2-3):105-16. doi: 10.1007/BF01243270.

A quantitative study in the rat on the relationship between imipramine levels in brain and serum.一项关于大鼠脑内丙咪嗪水平与血清中丙咪嗪水平关系的定量研究。

Psychopharmacology (Berl). 1982;76(1):48-51. doi: 10.1007/BF00430754.

The effect of imipramine and desipramine on mixed function oxidase in rats.丙咪嗪和去甲丙咪嗪对大鼠混合功能氧化酶的作用。

Naunyn Schmiedebergs Arch Pharmacol. 1984 Nov;328(1):83-6. doi: 10.1007/BF00496111.

Cerebral and blood pharmacokinetics of imipramine and its active metabolites in the pregnant rat.丙咪嗪及其活性代谢产物在妊娠大鼠体内的脑内和血液药代动力学

Psychopharmacology (Berl). 1984;84(2):225-30. doi: 10.1007/BF00427450.

Quantification of imipramine and its major metabolites in whole blood, brain, and other tissues of the rat by liquid chromatography.采用液相色谱法对大鼠全血、脑及其他组织中的丙咪嗪及其主要代谢产物进行定量分析。

Psychopharmacology (Berl). 1984;84(1):39-41. doi: 10.1007/BF00432021.

Effect of prenatal and postnatal exposure to therapeutic doses of chlorimipramine on emotionality in the rat.产前和产后暴露于治疗剂量的氯米帕明对大鼠情绪的影响。

Psychopharmacology (Berl). 1983;79(2-3):236-41. doi: 10.1007/BF00427819.

Clinical significance of plasma imipramine levels.血浆丙咪嗪水平的临床意义。

Proc R Soc Med. 1971 Mar;64(3):282-5. doi: 10.1177/003591577106400322.

Metabolism of 14 C-imipramine. 3. Conversions by rat tissues.14C-丙咪嗪的代谢。3. 大鼠组织的转化

Psychopharmacologia. 1970 Aug 19;18(1):26-37. doi: 10.1007/BF00402381.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验