Rodríguez Echandía E L, Broitman S T
Psychopharmacology (Berl). 1983;79(2-3):236-41. doi: 10.1007/BF00427819.
Prenatal administration of high doses of tricyclic antidepressants have been reported to produce teratogenic and behavioral effects in rat offspring. In the present work, behavioral abnormalities are described in offspring of rats treated with therapeutic doses of chlorimipramine (CIM) during pregnancy (CIM-P), lactation (CIM-L) and during the whole pregnancy-lactation period (CIM-PL). CIM-P treatment did not produce teratogenic effects, did not affect number or body weight of pups at birth and did not induce neonatal mortality. At 2 months of age, the CIM-P males showed a significant increase in digging and grooming (familiar environment test), a decrease in "exploration" (novel environment test) and a decrease in active social interactions (social behavior test). Females were more resistant than males to the prenatal CIM treatment. The results suggest increased emotionality in CIM-P pups. Some behavioral abnormalities were also observed in the tests performed at 4 months of age. CIM-L treatment had minor effects on litter behavior. CIM-PL treatment potentiated the effects of the CIM-P treatment. In the CIM-PL males, impairment of exploration of a novel environment still remained in the tests performed at 4 months of age. It is speculated that when prenatal brain development is altered by CIM, further postnatal treatment may impair compensatory processes occurring in early postnatal life.
据报道，产前给予高剂量三环类抗抑郁药会对大鼠后代产生致畸和行为影响。在本研究中，描述了孕期（CIM-P）、哺乳期（CIM-L）以及整个妊娠-哺乳期（CIM-PL）接受治疗剂量氯米帕明（CIM）处理的大鼠后代的行为异常情况。CIM-P处理未产生致畸作用，不影响出生时幼崽数量或体重，也未导致新生儿死亡。在2月龄时，CIM-P雄性幼崽在挖掘和梳理行为（熟悉环境试验）方面显著增加，“探索”行为（新环境试验）减少，主动社交互动（社交行为试验）减少。雌性比雄性对产前CIM处理更具抵抗力。结果表明CIM-P幼崽的情绪性增加。在4月龄时进行的试验中也观察到一些行为异常。CIM-L处理对窝内行为影响较小。CIM-PL处理增强了CIM-P处理的效果。在CIM-PL雄性幼崽中，在4月龄时进行的试验中对新环境的探索受损情况仍然存在。据推测，当产前脑发育因CIM而改变时，产后进一步的处理可能会损害出生后早期发生的代偿过程。
