吗啡对大鼠的抗利尿作用：耐受性与身体依赖性。
Antidiuretic effect of morphine in the rat: tolerance and physical dependence.
作者信息
Huidobro F
出版信息
Br J Pharmacol. 1978 Oct;64(2):167-71. doi: 10.1111/j.1476-5381.1978.tb17286.x.
Abstract
1 Injection of rats with morphine or methadone, before they received a water load equivalent to 5% of their body weight, produced a dose-dependent antidiuretic effect. Following the antidiuresis, urine was eliminated with kinetics similar to control untreated rats. 2 The antidiuretic effect of morphine or methadone was blocked by naloxone administered before the opiate, or reversed when given after the opiate. 3 Rats implanted with morphine pellets developed a marked degree of tolerance to the antidiuretic effect of morphine. Tolerance was also obtained on injection of three daily doses of morphine or methadone over two days. 4 Withdrawal symptoms were precipitated by naloxone in rats implanted with pellets of morphine; under these conditions the animals showed a marked reduction in urine production as compared to naive rats.
摘要
- 在给大鼠注射相当于其体重5%的水负荷之前，注射吗啡或美沙酮会产生剂量依赖性抗利尿作用。抗利尿作用之后，尿液排出的动力学与未处理的对照大鼠相似。2. 吗啡或美沙酮的抗利尿作用在给予阿片类药物之前注射纳洛酮可被阻断，或在给予阿片类药物之后注射则可被逆转。3. 植入吗啡丸剂的大鼠对吗啡的抗利尿作用产生了明显程度的耐受性。在两天内每日注射三次吗啡或美沙酮也可获得耐受性。4. 植入吗啡丸剂的大鼠注射纳洛酮会引发戒断症状；在这些条件下，与未接触过药物的大鼠相比，动物的尿量明显减少。
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