通过吡啶甲酸使NRK细胞同步于G(1)期时的铁转运
Iron transport in NRK cells synchronized in G(1) by picolinic acid.
作者信息
Fernandez-Pol J A, Klos D, Donati R M
出版信息
Cell Biol Int Rep. 1978 Sep;2(5):433-9. doi: 10.1016/0309-1651(78)90094-2.
PMID:568516
Abstract
NRK cells treated with picolinic acid are arrested in G(1)(G0). After removal of the agent a wave of transferrin-dependent iron uptake was observed only in early G(1). Therefore, iron transport is a primary event in the reinitiation of cell growth and may be connected with subsequent metabolic steps leading to initiation of DNA synthesis.
摘要
用吡啶甲酸处理的NRK细胞停滞在G1（G0）期。去除该试剂后，仅在G1早期观察到一波转铁蛋白依赖性铁摄取。因此，铁转运是细胞生长重新启动的主要事件，并且可能与导致DNA合成起始的后续代谢步骤相关。
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