哺乳动物组织在体外由环丙烷羧酸生物合成环丙基长链脂肪酸。
Biosynthesis of cyclopropyl long-chain fatty acids from cyclopropanecarboxylic acid by mammalian tissues in vitro.
作者信息
Duncombe W G, Rising T J
出版信息
Biochem J. 1968 Sep;109(3):449-55. doi: 10.1042/bj1090449.
Abstract
- Radioactivity from cyclopropane[(14)C]carboxylic acid is incorporated into fatty acids in vitro by rat and guinea-pig adipose tissue, by rat liver slices and by the supernatant fraction of rat liver homogenate. 2. The labelled acids are different from endogenous straight-chain fatty acids, and evidence is produced that they consist of a cyclopropyl ring in the omega-position, the remainder of the chain being built up from C(2) units (not derived from cyclopropanecarboxylic acid) in the normal way via the malonate pathway. 3. It is suggested that these unnatural acids have some metabolic effect related to the hypoglycaemic action of cyclopropanecarboxylic acid.
摘要
- 环丙烷[¹⁴C]羧酸的放射性在体外可被大鼠和豚鼠的脂肪组织、大鼠肝脏切片以及大鼠肝脏匀浆的上清液部分整合到脂肪酸中。2. 标记的酸与内源性直链脂肪酸不同，有证据表明它们在ω位含有一个环丙基环，链的其余部分通过丙二酸途径以正常方式由C₂单位（并非来自环丙烷羧酸）构建而成。3. 有人提出，这些非天然酸具有一些与环丙烷羧酸的降血糖作用相关的代谢效应。
相似文献
1
Biosynthesis of cyclopropyl long-chain fatty acids from cyclopropanecarboxylic acid by mammalian tissues in vitro.哺乳动物组织在体外由环丙烷羧酸生物合成环丙基长链脂肪酸。
Biochem J. 1968 Sep;109(3):449-55. doi: 10.1042/bj1090449.
2
Studies on the hypoglycaemic compound cyclopropanecarboxylic acid. Effects on fatty acid oxidation in vitro.关于降血糖化合物环丙烷羧酸的研究。对体外脂肪酸氧化的影响。
Biochem Pharmacol. 1972 Apr 15;21(8):1075-88. doi: 10.1016/0006-2952(72)90101-3.
3
Cyclopropanecarboxylic acid: chain elongation to omega-cyclopropyl fatty acids by mammals and plants.环丙烷羧酸：哺乳动物和植物将其链延长为ω-环丙基脂肪酸。
Science. 1978 Feb 3;199(4328):544-5. doi: 10.1126/science.622554.
4
Biochemical effects of the hypoglycaemic compound pent-4-enoic acid and related non-hypoglycaemic fatty acids. Carbohydrate metabolism.降血糖化合物戊-4-烯酸及相关非降血糖脂肪酸的生化效应。碳水化合物代谢。
Biochem J. 1968 Dec;110(3):521-7. doi: 10.1042/bj1100521.
5
Biochemical effects of the hypoglycaemic compound pent--4-enoic acid and related non-hypoglycaemic fatty acids.降血糖化合物戊-4-烯酸及相关非降血糖脂肪酸的生化效应。
Biochem J. 1968 Dec;110(3):511-9. doi: 10.1042/bj1100511.
6
Synthesis of fatty acids from (1- 14 C)acetyl-coenzyme A in subcellular particles of rat epididymal adipose tissue.大鼠附睾脂肪组织亚细胞颗粒中由（1-¹⁴C）乙酰辅酶A合成脂肪酸
Biochem J. 1972 Jul;128(4):847-57. doi: 10.1042/bj1280847.
7
Studies on the hypoglycaemic compound cyclopropanecarboxylic acid. Effects on gluconeogenesis in vitro.
Biochem Pharmacol. 1972 Apr 15;21(8):1089-96. doi: 10.1016/0006-2952(72)90102-5.
8
The carbon pathway for lipogenesis in isolated adipocytes from rat, guinea pig, and human adipose tissue.大鼠、豚鼠和人类脂肪组织中分离出的脂肪细胞内脂肪生成的碳途径。
Am J Clin Nutr. 1976 May;29(5):540-5. doi: 10.1093/ajcn/29.5.540.
9
Lipid biosynthesis in adipose tissue during aging and in diabetes.
Ann N Y Acad Sci. 1965 Oct 8;131(1):344-56. doi: 10.1111/j.1749-6632.1965.tb34802.x.
10
Metabolism of cyclopropane fatty acids oxidation of cis-9,10-methylene hexadecanoic and cis-9,10-methylene octadecanoic acids by rat-liver mitochondria.
Biochim Biophys Acta. 1966 Apr 4;116(2):205-13. doi: 10.1016/0005-2760(66)90003-8.
引用本文的文献
1
Biochemical effects of the hypoglycaemic compound pent-4-enoic acid and related non-hypoglycaemic fatty acids. Effects of the free acids and their carnitine esters on coenzyme A-dependent oxidations in rat liver mitochondria.降血糖化合物戊-4-烯酸及相关非降血糖脂肪酸的生化效应。游离酸及其肉碱酯对大鼠肝线粒体中辅酶A依赖性氧化的影响。
Biochem J. 1973 Sep;136(1):157-71. doi: 10.1042/bj1360157.
本文引用的文献
1
Ring location in cyclopropane fatty acid esters by a mass spectrometric method.采用质谱法测定环丙烷脂肪酸酯中环的位置
Lipids. 1967 May;2(3):225-30. doi: 10.1007/BF02532560.
2
Cyclopropane ring blosynthesis.环丙烷环生物合成。
Biochemistry. 1962 Jan;1:189-91. doi: 10.1021/bi00907a028.
3
cis-9,10-Methylene hexadecanoic acid from the phospholipids of Escherichia coli.来自大肠杆菌磷脂的顺式-9,10-亚甲基十六烷酸。
J Biol Chem. 1961 Oct;236:2615-9.
4
CYCLOPROPANE FATTY ACID METABOLISM: PHYSICAL AND CHEMICAL IDENTIFICATION OF PROPANE RING METABOLIC PRODUCTS IN THE ADIPOSE TISSUE.环丙烷脂肪酸代谢：脂肪组织中环丙烷环代谢产物的物理和化学鉴定
J Am Oil Chem Soc. 1965 Apr;42:315-20. doi: 10.1007/BF02540137.
5
LIPID METABOLISM.脂质代谢
Annu Rev Biochem. 1964;33:139-72. doi: 10.1146/annurev.bi.33.070164.001035.
6
THE DETERMINATION OF THE FATTY ACID COMPOSITION OF SERUM LIPIDS SEPARATED BY THIN-LAYER CHROMATOGRAPHY; AND A COMPARISON WITH COLUMN CHROMATOGRAPHY.用薄层色谱法分离血清脂质并测定其脂肪酸组成；与柱色谱法的比较。
Biochim Biophys Acta. 1963 Aug 27;70:423-31. doi: 10.1016/0006-3002(63)90772-8.
7
A simple device for the rapid routine liberation and trapping of C-14-02 for scintillation counting.一种用于快速常规释放和捕集用于闪烁计数的C-14-02的简单装置。
Int J Appl Radiat Isot. 1961 Aug;11:47-8. doi: 10.1016/0020-708x(61)90156-9.
8
The effect of some cofactors on the synthesis of fatty acids and cholesterol in cell-fre preparations of rat liver.某些辅助因子对大鼠肝脏无细胞制剂中脂肪酸和胆固醇合成的影响。
J Physiol. 1961 Mar;155(3):498-505. doi: 10.1113/jphysiol.1961.sp006642.
9
A simple method for the isolation and purification of total lipides from animal tissues.一种从动物组织中分离和纯化总脂质的简单方法。
J Biol Chem. 1957 May;226(1):497-509.
Zotero 插件