降血糖化合物戊-4-烯酸及相关非降血糖脂肪酸的生化效应。碳水化合物代谢。
Biochemical effects of the hypoglycaemic compound pent-4-enoic acid and related non-hypoglycaemic fatty acids. Carbohydrate metabolism.
作者信息
Senior A E, Sherratt H S
出版信息
Biochem J. 1968 Dec;110(3):521-7. doi: 10.1042/bj1100521.
Abstract
- The effects of the hypoglycaemic compound, pent-4-enoic acid, and of four structurally related non-hypoglycaemic compounds (pent-2-enoic acid, pentanoic acid, cyclopropanecarboxylic acid and cyclobutanecarboxylic acid), on glycolysis, glucose oxidation and gluconeogenesis in some rat tissues were determined. 2. None of the compounds at low concentrations inhibited glycolysis by particle-free supernatant fractions from rat liver, skeletal muscle and intestinal mucosa, though there was inhibition by cyclopropanecarboxylic acid and cyclobutanecarboxylic acid at 3mm concentration. 3. Pent-4-enoic inhibited the oxidation of [1-(14)C]palmitate by rat liver slices, but did not increase the oxidation of [U-(14)C]glucose. 4. Pent-4-enoic acid (0.01mm) strongly inhibited gluconeogenesis by rat kidney slices from pyruvate or succinate, but none of the other compounds inhibited significantly at low concentrations. 5. There was also some inhibition of gluconeogenesis in kidney slices from rats injected with pent-4-enoic acid. 6. The mechanism of the hypoglycaemic effect of pent-4-enoic acid is discussed; it is suggested that there is an inhibition of fatty acid and ketone-body oxidation and of gluconeogenesis so that glucose reserves become exhausted, leading to hypoglycaemia. 7. The mechanism of the hypoglycaemic action of pent-4-enoic acid appears to be similar to that of hypoglycin.
摘要
- 测定了降糖化合物戊-4-烯酸以及四种结构相关的非降糖化合物（戊-2-烯酸、戊酸、环丙烷羧酸和环丁烷羧酸）对大鼠某些组织中糖酵解、葡萄糖氧化和糖异生的影响。2. 低浓度时，这些化合物均未抑制大鼠肝脏、骨骼肌和肠黏膜无细胞上清液组分的糖酵解，不过环丙烷羧酸和环丁烷羧酸在3mmol浓度时存在抑制作用。3. 戊-4-烯酸抑制大鼠肝切片中[1-(14)C]棕榈酸的氧化，但未增加[U-(14)C]葡萄糖的氧化。4. 戊-4-烯酸（0.01mmol）强烈抑制大鼠肾切片由丙酮酸或琥珀酸生成葡萄糖的过程，但其他化合物在低浓度时均无明显抑制作用。5. 给大鼠注射戊-4-烯酸后，其肾切片中的糖异生也受到一定抑制。6. 讨论了戊-4-烯酸的降糖作用机制；有人提出，它抑制脂肪酸和酮体的氧化以及糖异生，从而使葡萄糖储备耗尽，导致低血糖。7. 戊-4-烯酸的降糖作用机制似乎与降糖氨酸的相似。
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Biochemical effects of the hypoglycaemic compound pent-4-enoic acid and related non-hypoglycaemic fatty acids. Carbohydrate metabolism.降血糖化合物戊-4-烯酸及相关非降血糖脂肪酸的生化效应。碳水化合物代谢。
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2
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