通过模板合成部分拆分DL-腺苷。

Partial resolution of DL-adenosine by template synthesis.

作者信息

Schneider-Bernloehr H, Lohrmann R, Orgel L E, Sulston J, Weimann B J

出版信息

Science. 1968 Nov 15;162(3855):809-10. doi: 10.1126/science.162.3855.809.

DOI:10.1126/science.162.3855.809

Abstract

D-Adenosine-5'-phosphorimidazolide reacts very much more rapidly with D-adenosine than with L-adenosine on a poly-D-uridylic acid template. This permits the partial resolution of DL-adenosine. These experiments suggest that segregation of D- and L-nucleotides may have occurred at an early stage in biochemical evolution.

摘要

在聚-D-尿苷酸模板上，D-腺苷-5'-磷酰咪唑与D-腺苷的反应比与L-腺苷的反应快得多。这使得DL-腺苷得以部分拆分。这些实验表明，D-核苷酸和L-核苷酸的分离可能在生物化学进化的早期阶段就已发生。