Weis E E, Barth C A
J Lipid Res. 1978 Sep;19(7):856-62.
A new model is described which allows measurement of bile flow and sampling of bile in the intact rat with a physiologically functioning sphincter of Oddi. A number of metabolic parameters have been followed to show that animals with such an "extracorporeal bile duct" (EBD) behave as intact controls. Especially, there was no difference in the increase in body weight or hepatic fatty acid and cholesterol synthesis between EBD animals and intact controls. The amount of bile salts circulating through the biliary tract amounted to 30.5+/-1.5mumol . 100 g body wt-1 . hr-1, when diurnal variations were averaged. Animals adapted to a restricted feeding regimen showed a significant increase of bile flow and of biliary bile salt and cholesterol excretion during feeding (10AM-3 PM); these parameters reached their maximum 3 hours after onset of food intake.
本文描述了一种新模型，该模型能够在具有生理功能的奥迪括约肌的完整大鼠中测量胆汁流量并采集胆汁样本。已经跟踪了一些代谢参数，以表明具有这种“体外胆管”（EBD）的动物的行为与完整对照动物相同。特别是，EBD动物与完整对照动物在体重增加或肝脏脂肪酸及胆固醇合成方面没有差异。当平均昼夜变化时，流经胆道的胆汁盐量为30.5±1.5μmol·100g体重-1·小时-1。适应限制饮食方案的动物在进食期间（上午10点至下午3点）胆汁流量以及胆汁盐和胆固醇排泄量显著增加；这些参数在进食开始后3小时达到最大值。
