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胆管结扎大鼠胆汁排泄机制的变化

Changes in biliary excretory mechanisms in bile duct-ligated rat.

作者信息

Takikawa H, Wako Y, Sano N, Yamanaka M

机构信息

Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.

出版信息

Dig Dis Sci. 1996 Feb;41(2):256-62. doi: 10.1007/BF02093813.

Abstract

The effects of bile duct ligation on biliary excretion of bile acids, glutathione, and lipids were studied in the rat. The bile duct of the rat was ligated for three days. The biliary bile acid excretion after bile duct cannulation was higher at first, but after 90 min became lower than that in the control rat. The bile flow in the bile duct-ligated rat was higher after bile duct cannulation and gradually decreased to the same level as in the control rat. Biliary glutathione excretion, which has been suggested to be a driving force for the bile acid-independent canalicular bile flow, was markedly decreased in the bile duct-ligated rat. The mannitol clearance was increased and the bile ductules showed proliferation in the bile duct-ligated rat, suggesting an increase in the ductular bile flow. Biliary excretion of lithocholate glucuronide was more markedly impaired than that of taurocholate. When taurocholate was infused at higher rates, which increases bile flow and biliary excretion of bile acid and lipids in the control rat, biliary bile acid and lipid excretion remained constant in the bile duct-ligated rat. These findings indicate that, in the bile duct-ligated rat, the ductular bile flow was increased and bile acid-independent canalicular bile flow was decreased and that, although the biliary excretion of bile acids was not as impaired as that of organic anions, the capacity of bile acid and lipid excretion was markedly decreased.

摘要

在大鼠中研究了胆管结扎对胆汁酸、谷胱甘肽和脂质胆汁排泄的影响。将大鼠的胆管结扎三天。胆管插管后,起初胆管胆汁酸排泄较高,但90分钟后低于对照大鼠。胆管结扎大鼠胆管插管后的胆汁流量较高,随后逐渐降至与对照大鼠相同的水平。在胆管结扎大鼠中,被认为是不依赖胆汁酸的胆小管胆汁流动驱动力的胆管谷胱甘肽排泄明显减少。甘露醇清除率增加,胆管结扎大鼠的胆小管出现增殖,提示胆小管胆汁流量增加。石胆酸葡萄糖醛酸苷的胆汁排泄比牛磺胆酸盐更明显受损。当以较高速率输注牛磺胆酸盐时,可增加对照大鼠的胆汁流量以及胆汁酸和脂质的胆汁排泄,但在胆管结扎大鼠中,胆汁酸和脂质的胆汁排泄保持恒定。这些发现表明,在胆管结扎大鼠中,胆小管胆汁流量增加,不依赖胆汁酸的胆小管胆汁流量减少,并且尽管胆汁酸的胆汁排泄不如有机阴离子受损严重,但胆汁酸和脂质排泄能力明显降低。

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