Takahashi K, Hirose Y, Haneda A, Mizukami T, Okamura K, Suzuki M
Tohoku J Exp Med. 1978 Dec;126(4):325-33. doi: 10.1620/tjem.126.325.
After inserting the Cu-IUD and plastic-IUD into the horn of the uterus of rats, vaginal smears were daily observed for twelve estrus cycles, but no abnormal changes were noted. The female rats with the IUD were exposed to impregnation placing together with male rats. Neither the Cu-IUD nor the plastic-IUD affected copulation, and a complete contraceptive result was obtained in these rats. There were no significant differences in any effect examined between Cu-IUD and plastic-IUD groups. In order to investigate the influence of copper on the penetration of sperm, we placed the rats with the IUD under direct observation and then exposed them to natural copulation. By examining various sites of the reproductive organs 30 min after copulation, the hindrance of sperm migration by the Cu-IUD was confirmed.
将铜宫内节育器（Cu-IUD）和塑料宫内节育器插入大鼠子宫角后，每天观察阴道涂片，持续观察十二个发情周期，但未发现异常变化。将带有宫内节育器的雌性大鼠与雄性大鼠放在一起使其受孕。Cu-IUD和塑料宫内节育器均不影响交配，并且这些大鼠均获得了完全的避孕效果。Cu-IUD组和塑料宫内节育器组在任何所检测的效应方面均无显著差异。为了研究铜对精子穿透的影响，我们将带有宫内节育器的大鼠置于直接观察下，然后使其自然交配。通过在交配后30分钟检查生殖器官的各个部位，证实了Cu-IUD对精子迁移的阻碍作用。
