Grundsell H
J Reprod Fertil. 1975 Mar;42(3):447-58. doi: 10.1530/jrf.0.0420447.
The influence of a copper IUD on the incorporation of [3H]thymidine and [5-3H]uridine into the endometrium of the rabbit was studied during early pregnancy. The effect of the copper device was compared with those of polyethylene and platinum IUDs. The comparison showed that the presence of a copper IUD resulted in a significantly lower incorporation of [3H]thymidine on the 3rd day of pregnancy and in a higher incorporation of [3H]thymidine and [5-3H]uridine on the 5th day of pregnancy. The increase in the total amount of DNA in the endometrium in early pregnancy was markedly reduced in the copper IUD-containing horn, and autoradiography showed that the labelling frequency of epithelial cells in the endometrium was significantly reduced. A possible effect of the copper IUD on the stromal cells is discussed. These effects of copper could be due either to an altered hormonal responsiveness of the endometrium in the presence of copper or to a 'direct' effect of copper on nucleic acid metabolism.
在妊娠早期，研究了铜宫内节育器（IUD）对[3H]胸腺嘧啶核苷和[5-3H]尿苷掺入家兔子宫内膜的影响。将铜制节育器的作用与聚乙烯和铂制IUD的作用进行了比较。比较结果显示，铜IUD的存在导致妊娠第3天[3H]胸腺嘧啶核苷的掺入显著降低，而在妊娠第5天[3H]胸腺嘧啶核苷和[5-3H]尿苷的掺入增加。在含铜IUD的子宫角中，妊娠早期子宫内膜中DNA总量的增加明显减少，放射自显影显示子宫内膜上皮细胞的标记频率显著降低。文中讨论了铜IUD对基质细胞的可能作用。铜的这些作用可能是由于在有铜存在的情况下子宫内膜激素反应性改变，或者是铜对核酸代谢的“直接”作用。
