17β-雌二醇对培养肝细胞中蛋白质合成的调控
Regulation of protein synthesis by estradiol-17beta in cultured hepatocytes.
作者信息
Traniello S, Buzzoni M, Caruso A, Evangelisti R, Stabellini G, Carinci P
出版信息
Biochim Biophys Acta. 1978 Oct 24;520(3):664-70. doi: 10.1016/0005-2787(78)90151-x.
PMID:568939
Abstract
Estradiol-17beta added to cultured chick embryo hepatocytes induced the appearance in the medium of a phosphoprotein, identified as phosvitin on the basis of: (i) its behaviour on ionic exchange columns; (ii) its SDS-acrylamide gel electrophoretic mobility; (iii) its amino acid composition. The hormone treatment was also followed by a decreased synthesis of other proteins secreted by the hepatocytes.
摘要
添加到培养的鸡胚肝细胞中的17β-雌二醇诱导培养基中出现一种磷蛋白，基于以下几点鉴定为卵黄高磷蛋白：（i）其在离子交换柱上的行为；（ii）其SDS-丙烯酰胺凝胶电泳迁移率；（iii）其氨基酸组成。激素处理后，肝细胞分泌的其他蛋白质的合成也减少。
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