潜在的抗白血病和免疫抑制药物。某些苯并-2,1,3-恶二唑（苯并呋咱）及其N-氧化物（苯并呋咱-N-氧化物）的制备及体外药理活性。 - Suppr

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Potential antileukemic and immunosuppressive drugs. Preparation and in vitro pharmacological acitivity of some benzo-2,1,3-oxadiazoles (benzofurazans) and their N-oxides (benzofuroxans).

作者信息

Ghosh P B, Whitehouse M W

出版信息

J Med Chem. 1968 Mar;11(2):305-11. doi: 10.1021/jm00308a027.

DOI:10.1021/jm00308a027

PMID:5690956

Abstract

摘要

相似文献

Potential antileukemic and immunosuppressive drugs. Preparation and in vitro pharmacological acitivity of some benzo-2,1,3-oxadiazoles (benzofurazans) and their N-oxides (benzofuroxans).潜在的抗白血病和免疫抑制药物。某些苯并-2,1,3-恶二唑（苯并呋咱）及其N-氧化物（苯并呋咱-N-氧化物）的制备及体外药理活性。

J Med Chem. 1968 Mar;11(2):305-11. doi: 10.1021/jm00308a027.

Potential antileukemic and immunosuppressive drugs. II. Further studies with benzo-2,1,3-oxadiazoles (benzofurazans) and their N-oxides (benzofuroxans).潜在的抗白血病和免疫抑制药物。II. 苯并-2,1,3-恶二唑（苯并呋咱）及其N-氧化物（苯并呋咱-N-氧化物）的进一步研究。

J Med Chem. 1969 May;12(3):505-7. doi: 10.1021/jm00303a606.

Potential antileukemic and immunosuppressive drugs. 3. Effects of homocyclic ring substitution on the in vitro drug activity of 4-nitrobenzo-2,1,3-oxadiazoles (4-nitrobenzofurazans) and their N-oxides (4-nitrobenzofuroxans).潜在的抗白血病和免疫抑制药物。3. 同环取代对4-硝基苯并-2,1,3-恶二唑（4-硝基苯并呋咱）及其N-氧化物（4-硝基苯并呋咱氧化物）体外药物活性的影响。

J Med Chem. 1972 Mar;15(3):255-60. doi: 10.1021/jm00273a012.

Synthesis and biological evaluation of 1,2,5-oxadiazole N-oxide derivatives as hypoxia-selective cytotoxins.1,2,5-恶二唑氮氧化物衍生物作为缺氧选择性细胞毒素的合成及生物学评价

Pharmazie. 1998 Nov;53(11):758-64.

4-nitrobenzofurazans and 4-nitrobenzofuroxans: a new class of thiol-neutralising agents and potent inhibitors of nucleic acid synthesis in leucocytes.4-硝基苯并呋喃和4-硝基苯并呋咱：一类新型的硫醇中和剂及白细胞核酸合成的强效抑制剂。

Biochem Pharmacol. 1968 Jan;17(1):158-61. doi: 10.1016/0006-2952(68)90169-x.

[Synthesis and properties of semisynthetic penicillins containing the furoxan nucleus].含呋咱环的半合成青霉素的合成与性质

Farmaco Sci. 1975 Nov;30(11):900-3.

Furazanobenzofuroxan, furazanobenzothiadiazole, and their N-oxides. A new class of vasodilator drugs.

J Med Chem. 1974 Feb;17(2):203-6. doi: 10.1021/jm00248a013.

Nucleic acids. 11. Synthesis of 5'-esters of 1-beta-D-arabinofuranosylcytosine possessing antileukemic and immunosuppressive activity.核酸。11. 具有抗白血病和免疫抑制活性的1-β-D-阿拉伯呋喃糖基胞嘧啶5'-酯的合成。

J Med Chem. 1971 Dec;14(12):1159-62. doi: 10.1021/jm00294a004.

Furoxan derivatives as cytotoxic agents: preliminary in vivo antitumoral activity studies.

Pharmazie. 2006 Jan;61(1):54-9.

Benzofurazans and benzofuroxans: biochemical and pharmacological properties.苯并呋咱和苯并氧化呋咱：生化与药理学性质

Med Res Rev. 1981 Summer;1(2):159-87. doi: 10.1002/med.2610010203.

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