腐败梭菌和溶组织梭菌毒素的共同成分与特定成分研究。
Investigation of common and specific components of Cl. septicum and Cl. histolyticum toxins.
作者信息
Zemlyanitskaya E P, Yermakova M P, Matveyev K I
出版信息
J Hyg Epidemiol Microbiol Immunol. 1978;22(1):108-14.
Interrelations between the common and specific components in the toxins of several strains of Cl. septicum and Cl. histolyticum were investigated. The method of tissue culture, which yields more stable results than biological tests on animals, was used. It has been demonstrated that native toxins of Cl. seticum (7 strains) and Cl. histolyticum (7 strains) cause cytotoxic changes in chick embryo fibroblasts. These changes are similar to each other and identical with changes occurring under the effect of concentrated toxins of the mentioned microorganisms. Cross reactions of neutralization with antitoxic and species-specific sera against Cl. septicum and Cl. histolyticum have shown that the strains of Cl. septicum and Cl. histolyticum synthesize toxins with components possessing common antigenic properties. The strains of Cl. histolyticum synthesize a greater amount of components common with Cl. septicum than the strains of Cl. septicum in which the amount of heterologous antigens varies.
对几种败血梭菌和溶组织梭菌菌株毒素中的共同成分与特定成分之间的相互关系进行了研究。采用了组织培养方法，该方法比在动物身上进行的生物学试验能产生更稳定的结果。已证明，败血梭菌（7株）和溶组织梭菌（7株）的天然毒素会引起鸡胚成纤维细胞的细胞毒性变化。这些变化彼此相似，且与上述微生物浓缩毒素作用下发生的变化相同。用针对败血梭菌和溶组织梭菌的抗毒素和种特异性血清进行的中和交叉反应表明，败血梭菌和溶组织梭菌菌株合成的毒素成分具有共同的抗原特性。溶组织梭菌菌株合成的与败血梭菌共有的成分比败血梭菌菌株更多，而败血梭菌菌株中异源抗原的含量有所不同。
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