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二价阳离子对心脏副交感神经末梢乙酰胆碱释放的影响。

Effect of divalent cations on acetylcholine release from cardiac parasympathetic nerve endings.

作者信息

Glitsch H G, Pott L

出版信息

Pflugers Arch. 1978 Oct 18;377(1):57-63. doi: 10.1007/BF00584374.

DOI:10.1007/BF00584374
PMID:569281
Abstract

The influence of several divalent cations on acetylcholine (ACh) release from vagus nerve terminals was studied in quiescent guinea-pig auricles. ACh release was induced by stimulus trains subthreshold for excitation of atrial cells. The ACh released evoked a hyperpolarization of the atrial cell membrane. Changes in ACh sensitivity of the atrial cell membrane were tested by application of ACh-containing solutions. ACh release increased with the external Ca concentration. External Sr maintained the ACh release in 'Ca-free' media. However, Sr ions were less effective than Ca ions. External Mg acted as a weak inhibitor of the stimulus evoked ACh release, whereas Co and Mn ions exerted a strong inhibition.

摘要

在静态豚鼠心房中研究了几种二价阳离子对迷走神经末梢乙酰胆碱（ACh）释放的影响。通过低于心房细胞兴奋阈值的刺激串诱导ACh释放。释放的ACh引起心房细胞膜超极化。通过应用含ACh溶液测试心房细胞膜对ACh敏感性的变化。ACh释放随细胞外Ca浓度增加。在“无Ca”培养基中，细胞外Sr维持ACh释放。然而，Sr离子的作用比Ca离子弱。细胞外Mg作为刺激诱发ACh释放的弱抑制剂，而Co和Mn离子则发挥强抑制作用。

相似文献

1
Effect of divalent cations on acetylcholine release from cardiac parasympathetic nerve endings.二价阳离子对心脏副交感神经末梢乙酰胆碱释放的影响。
Pflugers Arch. 1978 Oct 18;377(1):57-63. doi: 10.1007/BF00584374.
2
Facilitation of acetylcholine release from cardiac parasympathetic nerve endings. Effect of stimulation pattern and Mn ions.
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引用本文的文献

1
Facilitation of acetylcholine release from cardiac parasympathetic nerve endings. Effect of stimulation pattern and Mn ions.
Pflugers Arch. 1981 Aug;391(2):105-11. doi: 10.1007/BF00656999.
2
On the time course of the acetylcholine-induced hyperpolarization in quiescent guinea-pig atria.关于乙酰胆碱诱导的静息豚鼠心房超极化的时间进程。
Pflugers Arch. 1979 May 15;380(1):71-7. doi: 10.1007/BF00582615.

本文引用的文献

1
Strontium as a substitute for calcium in the process of transmitter release at the neuromuscular junction.在神经肌肉接头处递质释放过程中锶作为钙的替代物。
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The nature of the antagonism between calcium and magnesium ions at the neuromuscular junction.神经肌肉接头处钙离子与镁离子之间拮抗作用的本质。
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Vagal and sympathetic effects on the pacemaker fibers in the sinus venosus of the heart.迷走神经和交感神经对心脏静脉窦起搏纤维的影响。
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Co-operative action a calcium ions in transmitter release at the neuromuscular junction.钙离子在神经肌肉接头处递质释放中的协同作用。
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Interaction between Na, Ca, Mg, and vagal stimulation in the S-A node of the rabbit.兔窦房结中钠、钙、镁与迷走神经刺激之间的相互作用。
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Modification of transmitter release by ions which prolong the presynaptic action potential.通过延长突触前动作电位的离子对递质释放的修饰。
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