Nilius B
Acta Biol Med Ger. 1978;37(3):453-62.
A mathematical model of pre- and postganglionic parasympathetic nerve fiber excitation transfer is developed. This model gives a measure Q of acetylcholine (ACh) release from presynaptic preganglionic boutons and postganglionic varicosities. When increasing Ca++ the measure Q increases too. Na-ions exert a competitive inhibition. The relationship between Q and the Ca/Na2-quotient is a hyperbolic one. Mn++ inhibits the release of ACh non-competitively. Q increases both by excess potassium and Cs+ depolarization. The ACh release is diminished by Mg++. Ba++ cannot replace the effect of Ca++ on ACh release in Ca++ depleting conditions. Q increases with decreasing pH-level. The ACh release is not significantly influenced by increasing pH, Verapamil (4 mg/l), prostaglandins E2 and F2alpha (20 ng/ml) and substitution of nonpermeable anions for Cl-.
建立了节前和节后副交感神经纤维兴奋传递的数学模型。该模型给出了从突触前节前终扣和节后曲张体释放乙酰胆碱（ACh）的量度Q。当增加Ca++时，量度Q也增加。Na+离子发挥竞争性抑制作用。Q与Ca/Na2商之间的关系是双曲线关系。Mn++非竞争性抑制ACh的释放。过量的钾和Cs+去极化都会使Q增加。Mg++会减少ACh的释放。在Ca++耗竭的条件下，Ba++不能替代Ca++对ACh释放的作用。Q随pH值降低而增加。增加pH值、维拉帕米（4毫克/升）、前列腺素E2和F2α（20纳克/毫升）以及用不可渗透阴离子替代Cl-对ACh释放没有显著影响。
