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生物活性化合物的体内抗病毒特性。II. 流感病毒和痘苗病毒相关研究。

In vivo antiviral properties of biologically active compounds. II. Studies with influenza and vaccinia viruses.

作者信息

Sidwell R W, Dixon G J, Sellers S M, Schabel F M

出版信息

Appl Microbiol. 1968 Feb;16(2):370-92. doi: 10.1128/am.16.2.370-392.1968.

DOI:10.1128/am.16.2.370-392.1968
PMID:5694419
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC547415/
Abstract

The in vivo anti-influenza virus and antivaccinia virus activity of 156 biologically active compounds was determined. One of two criteria was used for evaluating activity against the influenza virus. The criteria were increase in survivor number and mean survival time, and reduction in virus-induced lung consolidation in treated, infected Swiss mice. Increase in survivor number and mean survival time were the criteria for evaluation of antivaccinia virus activity. Several drug doses were tested against two virus concentrations to demonstrate antiviral activity more clearly. Two compounds were considered significantly active against the influenza virus: DL-noformicin (NSC 72942) and amantadine hydrochloride (NSC 83653). Eleven compounds had reproducible activity against vaccinia virus: isatin-beta-thiosemicarbazone (NSC 721), 6-azauracil (NSC 3425), 9-alpha-fluoro-2alpha-methylhydrocortisone 21-acetate (NSC 12601), 5-[bis(2-chloroethyl)amino]uracil (NSC 34462), 5-iodo-2'-deoxyuridine (NSC 39661), streptonigrin (NSC 45383), N-methylisatin beta-thiosemicarbazone (NSC 69811), cytovirin (NSC 91770), 9-beta-D-arabinofuranosyladenine (NSC 404241), and 5-(mercaptomethyl)uracil (NSC 529351).

摘要

测定了156种生物活性化合物的体内抗流感病毒和抗痘苗病毒活性。采用两个标准之一来评估抗流感病毒活性。这些标准是存活小鼠数量的增加和平均存活时间，以及经治疗的感染瑞士小鼠中病毒诱导的肺实变的减轻。存活小鼠数量的增加和平均存活时间是评估抗痘苗病毒活性的标准。针对两种病毒浓度测试了几种药物剂量，以更清楚地证明抗病毒活性。有两种化合物被认为对流感病毒具有显著活性：DL-诺夫米星（NSC 72942）和盐酸金刚烷胺（NSC 83653）。有11种化合物对痘苗病毒具有可重复的活性：异烟肼-β-硫代半卡巴腙（NSC 721）、6-氮尿嘧啶（NSC 3425）、9-α-氟-2α-甲基氢化可的松21-乙酸酯（NSC 12601）、5-[双（2-氯乙基）氨基]尿嘧啶（NSC 34462）、5-碘-2'-脱氧尿苷（NSC 39661）、链黑菌素（NSC 45383）、N-甲基异烟肼β-硫代半卡巴腙（NSC 69811）、细胞病毒素（NSC 91770）、9-β-D-阿拉伯呋喃糖基腺嘌呤（NSC 404241）和5-（巯基甲基）尿嘧啶（NSC 529351）。

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