甲型流感病毒在小鼠肺内增殖的定量研究；病毒增殖程度与肺炎程度之间的关系。
Quantitative aspects of the multiplication of influenza A virus in the mouse lung; relation between the degree of viral multiplication and the extent of pneumonia.
作者信息
GINSBERG H S, HORSFALL F L
出版信息
J Exp Med. 1952 Feb;95(2):135-45. doi: 10.1084/jem.95.2.135.
Abstract
Influenza A virus, PR8 strain, increases in amount in the infected mouse lung at a relatively constant rate. When more than 25 M.S.50 doses of virus is inoculated, the rate of multiplication appears to be independent of the amount of virus introduced; has a value of 1,100-fold increase per day. The rate of increase in the pulmonary lesions induced by infection of the mouse lung with PR8 also appears to be relatively constant and independent of the amount of virus inoculated; has a value of 8.5-fold increase per day. The essential variables in the PR8-mouse lung system appear to be equated satisfactorily by functions which were derived previously (4) during a similar quantitative investigation on pneumonia virus of mice (PVM). Evidence in support of the hypothesis that the processes of multiplication of PR8 and PVM are different in the mouse lung is presented.
摘要
甲型流感病毒PR8株在受感染的小鼠肺中以相对恒定的速率增殖。当接种超过25个半数致死量的病毒时，增殖速率似乎与引入的病毒量无关；每天增加1100倍。用PR8感染小鼠肺所诱导的肺部病变的增加速率也似乎相对恒定，且与接种的病毒量无关；每天增加8.5倍。在对小鼠肺炎病毒（PVM）进行的类似定量研究中，先前（4）推导的函数似乎令人满意地平衡了PR8-小鼠肺系统中的基本变量。本文提供了支持PR8和PVM在小鼠肺中的增殖过程不同这一假设的证据。
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