Kozlov A M, Sof'ina Z P
Biull Eksp Biol Med. 1978 Dec;86(12):715-8.
The character of metastasis of 9 strains of transplantable mouse tumours in conventional subcutaneous inoculation was studied. There were differences in the frequency, intensity, and types of metastasis of different tumours. Periods of onset of metastases of Lewis lung carcinoma and RL-67, and also of sarcoma-37 were established. Sarcoma, Lewis and RL-67 lung carcinomas, adenocarcinoma of the colon AKATOL, Cloudman's melanoma and B-16 metastasized most intensively. Sarcoma-37 metastasizing into the regional and remote lymph nodes, Lewis lung carcinoma and melanomas metastasizing into the lungs, RL-67 lung carcinoma metastasizing into the lungs, kidneys, adrenal glands, ovaries, the heart, and also adenocarcinoma of the colon AKATOL metastasizing into the lymph nodes and the liver can be used as models for the research in the field of drug action upon metastases and the metastasis process.
研究了9株可移植性小鼠肿瘤在常规皮下接种时的转移特性。不同肿瘤在转移频率、强度和类型上存在差异。确定了Lewis肺癌、RL - 67以及肉瘤 - 37转移的起始时间。肉瘤、Lewis肺癌、RL - 67肺癌、结肠腺癌AKATOL、Cloudman黑色素瘤和B - 16转移最为强烈。转移至局部和远处淋巴结的肉瘤 - 37、转移至肺部的Lewis肺癌和黑色素瘤、转移至肺部、肾脏、肾上腺、卵巢、心脏的RL - 67肺癌，以及转移至淋巴结和肝脏的结肠腺癌AKATOL，可作为研究药物对转移及转移过程作用领域的模型。
