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体外肿瘤细胞中微管重新组装——微管与孔复合物、内质网及100埃细丝之间的相互作用

Microtubule reassembly-interactions between microtubules and pore complexes, endoplasmic reticulum and 100 A filaments in tumour cells in vitro.

作者信息

Chemnitz J, Salmberg K

出版信息

Cytobiologie. 1978 Dec;18(2):320-6.

PMID:569605
Abstract

100 A filaments and annulate lamellae were often observed in the vicinity of vinblastine-induced paracrystals in tumour cells treated with nocodazole. There was often a direct continuity between 100 A filaments and paracrystals. The assembly of microtubules was examined in nocodazole-treated cells with special attention to possible initiating sites. We found an apparent association of microtubules with pore like structures associated with the endoplasmic reticulum. A complex system of 100 A filaments, microtubules and endoplasmic reticulum was observed. The significance of these results is discussed.

摘要

在用诺考达唑处理的肿瘤细胞中,经常在长春碱诱导的类晶体附近观察到100埃细丝和环孔板层。100埃细丝和类晶体之间常常有直接的连续性。在诺考达唑处理的细胞中检查了微管的组装,并特别关注了可能的起始位点。我们发现微管与内质网相关的孔状结构有明显的关联。观察到了一个由100埃细丝、微管和内质网组成的复杂系统。讨论了这些结果的意义。

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