抗惊厥药对血浆睾酮和性激素结合球蛋白水平的影响。
Effect of anticonvulsants on plasma testosterone and sex hormone binding globulin levels.
作者信息
Barragry J M, Makin H L, Trafford D J, Scott D F
出版信息
J Neurol Neurosurg Psychiatry. 1978 Oct;41(10):913-4. doi: 10.1136/jnnp.41.10.913.
Abstract
Plasma sex hormone binding globulin (SHBG) and testosterone levels were measured in 29 patients with epilepsy (16 men and 13 women), most of them on chronic therapy with anticonvulsant drugs. Sex hormone binding globulin concentrations were increased in both sexes and testosterone levels in male patients. It is postulated that anticonvulsants may induce hepatic synthesis of SHBG.
摘要
对29例癫痫患者（16名男性和13名女性）进行了血浆性激素结合球蛋白（SHBG）和睾酮水平测定，他们大多数正在接受抗惊厥药物的长期治疗。两性的性激素结合球蛋白浓度均升高，男性患者的睾酮水平升高。据推测，抗惊厥药可能会诱导肝脏合成SHBG。
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本文引用的文献
1
A rapid method for the measurement of sex hormone binding globulin capacity of sera.
Clin Chim Acta. 1974 Sep 16;55(2):165-78. doi: 10.1016/0009-8981(74)90293-9.
2
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Clin Endocrinol (Oxf). 1974 Jan;3(1):69-96. doi: 10.1111/j.1365-2265.1974.tb03298.x.
3
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