Torrance J D, Charlton R W, Schmaman A, Lynch S R, Bothwell T H
J Clin Pathol. 1968 Jul;21(4):495-500. doi: 10.1136/jcp.21.4.495.
In Bantu subjects with iron overload iron is visible in skeletal muscle cells and in the tissue histiocytes which lie between these cells. In the present study the concentrations of ;muscle' iron were measured chemically in subjects with varying hepatic storage iron concentrations. The results indicate that the concentrations of storage iron in ;muscle' are much lower than those in the liver. However, the muscle mass is so large that the total amount of iron present is at least equal to that in the liver in subjects with normal body stores. The concentrations of iron in ;muscle' are raised in subjects with iron overload but the degree to which they rise is far less than occurs in the liver; a thirtyfold increase in hepatic iron concentrations is associated with only a sixfold increase in ;muscle' iron. Experiments in rats revealed that storage iron in ;muscle' represents a relatively non-miscible pool which responds very little to acute changes in the iron environment.
在患有铁过载的班图族受试者中，铁可见于骨骼肌细胞以及位于这些细胞之间的组织组织细胞中。在本研究中，对具有不同肝脏储存铁浓度的受试者的“肌肉”铁浓度进行了化学测量。结果表明，“肌肉”中的储存铁浓度远低于肝脏中的浓度。然而，肌肉量如此之大，以至于在身体储存正常的受试者中，肌肉中铁的总量至少与肝脏中的相等。“肌肉”中铁的浓度在铁过载受试者中升高，但升高的程度远小于肝脏；肝脏铁浓度增加30倍仅与“肌肉”铁增加6倍相关。在大鼠身上进行的实验表明，“肌肉”中的储存铁代表了一个相对不混溶的池，对铁环境的急性变化反应很小。
