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1
Prophylactic folic acid in women with pernicious anaemia pregnant after periods of infertility.对患有恶性贫血且经历过不孕期后怀孕的女性进行预防性叶酸治疗。
J Clin Pathol. 1968 Sep;21(5):599-602. doi: 10.1136/jcp.21.5.599.
2
Pernicious anaemia as a cause of infertility.
Lancet. 1967 Dec 2;2(7527):1159-60. doi: 10.1016/s0140-6736(67)91887-9.
3
Pregnancy and untreated Addisonian pernicious anemia.妊娠与未经治疗的艾迪生病性恶性贫血
Br Med J. 1968 Oct 19;4(5624):158-9. doi: 10.1136/bmj.4.5624.158.
4
Does folic acid harm people with vitamin B12 deficiency?叶酸会对维生素B12缺乏的人造成伤害吗？
QJM. 1995 May;88(5):357-64.
5
The incidence of pernicious anaemia and the etiology of folic acid deficiency in pregnancy.恶性贫血的发病率及孕期叶酸缺乏的病因
Acta Obstet Gynecol Scand. 1967;46(S7):113-5. doi: 10.3109/00016346709157079.
6
MICROBIOLOGICAL ASSAY OF FOLIC ACID ACTIVITY IN HUMAN SERUM.人血清中叶酸活性的微生物学测定
J Clin Pathol. 1964 Nov;17(6):660-5. doi: 10.1136/jcp.17.6.660.
7
[Pernicious anemia as cause of secondary sterility].
Schweiz Med Wochenschr. 1984 Feb 4;114(5):178-9.
8
Studies on the folic acid activity of human serum.人体血清叶酸活性的研究。
J Clin Pathol. 1961 Jul;14(4):335-44. doi: 10.1136/jcp.14.4.335.
9
Pernicious anaemia as a cause of infertility.恶性贫血作为不孕的一个原因。
Lancet. 1971 Apr 10;1(7702):753. doi: 10.1016/s0140-6736(71)92017-4.
10
Pernicious anaemia and neurophysiological studies in Arabs.阿拉伯人中的恶性贫血与神经生理学研究
Int J Clin Pract. 2000 Apr;54(3):152-4.

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Evidence based recommendations for an optimal prenatal supplement for women in the US: vitamins and related nutrients.美国针对女性最佳产前补充剂的循证建议：维生素及相关营养素
Matern Health Neonatol Perinatol. 2022 Jul 11;8(1):4. doi: 10.1186/s40748-022-00139-9.
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Vitamin B12 Intake From Animal Foods, Biomarkers, and Health Aspects.来自动物性食物的维生素B12摄入量、生物标志物及健康方面
Front Nutr. 2019 Jun 28;6:93. doi: 10.3389/fnut.2019.00093. eCollection 2019.
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Mice lacking the transcobalamin-vitamin B12 receptor, CD320, suffer from anemia and reproductive deficits when fed vitamin B12-deficient diet.缺乏转钴胺素-维生素 B12 受体（CD320）的小鼠在喂食维生素 B12 缺乏饮食时会出现贫血和生殖缺陷。
Hum Mol Genet. 2018 Oct 15;27(20):3627-3640. doi: 10.1093/hmg/ddy267.

本文引用的文献

1
Megaloblastic anemia during pregnancy and the puerperium.
Am J Obstet Gynecol. 1962 Apr 15;83:1004-20. doi: 10.1016/s0002-9378(16)35934-8.
2
The significance of Howell-Jolly bodies in red cell precursors.豪-乔氏小体在红细胞前体中的意义。
J Clin Pathol. 1959 Sep;12(5):451-3. doi: 10.1136/jcp.12.5.451.
3
IRON DEFICIENCY AND ITS RELATION TO FOLIC-ACID STATUS IN PREGNANCY: RESULTS OF A CLINICAL TRIAL.缺铁及其与孕期叶酸状态的关系：一项临床试验的结果
Br Med J. 1965 Feb 20;1(5433):480-5. doi: 10.1136/bmj.1.5433.480.
4
Prevention of megalo-blastic anaemia in pregnancy by folic acid.叶酸预防妊娠期巨幼细胞贫血
Lancet. 1962 Nov 17;2(7264):1015-8. doi: 10.1016/s0140-6736(62)92702-2.
5
Seminal vitamin B-12 and sterility.精液中的维生素B-12与不育症
Lancet. 1963 Jan 5;1(7271):59-60. doi: 10.1016/s0140-6736(63)91195-4.
6
Obstetrical aspects of megaloblastic anaemia of pregnancy.
J Obstet Gynaecol Br Emp. 1962 Oct;69:736-8. doi: 10.1111/j.1471-0528.1962.tb01272.x.
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An evaluation of aminopterin as an abortifacient.
Am J Obstet Gynecol. 1962 Jun 1;83:1474-7. doi: 10.1016/s0002-9378(16)35992-0.
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Studies on the mechanism of action of estrogens.雌激素作用机制的研究。
Recent Prog Horm Res. 1958;14:95-129; discussion 130-9.
9
Pregnancy and Addisonian pernicious anaemia.
Scott Med J. 1958 Jan;3(1):21-5. doi: 10.1177/003693305800300103.
10
An investigation of folic acid requirements in pregnancy. II.孕期叶酸需求的调查。II.
Br J Haematol. 1967 Jul;13(4):503-9. doi: 10.1111/j.1365-2141.1967.tb00760.x.

对患有恶性贫血且经历过不孕期后怀孕的女性进行预防性叶酸治疗。

Prophylactic folic acid in women with pernicious anaemia pregnant after periods of infertility.

作者信息

Hall M, Davidson R J

出版信息

J Clin Pathol. 1968 Sep;21(5):599-602. doi: 10.1136/jcp.21.5.599.

DOI:10.1136/jcp.21.5.599
PMID:5697363
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC473871/
Abstract

The haematological and obstetric details of five women with Addisonian pernicious anaemia and infertility are described together with those of another patient who developed the anaemia soon after confinement. The implications are discussed, and it is concluded that the prophylactic administration of small doses of folic acid during pregnancy is a safe procedure while the risk of precipitating subacute combined degeneration of the cord in undiagnosed Addisonian pernicious anaemia is hypothetical. Although the mechanism of the infertility in pernicious anaemia remains undefined, several factors which may be of aetiological significance are considered.

摘要

本文描述了五例患有艾迪生病恶性贫血和不孕症的女性的血液学和产科详细情况，以及另一例产后不久患上该贫血症的患者的情况。文中讨论了其中的影响，并得出结论：孕期预防性给予小剂量叶酸是一种安全的做法，而在未确诊的艾迪生病恶性贫血中引发亚急性联合变性脊髓的风险只是一种假设。尽管恶性贫血导致不孕的机制尚不清楚，但文中考虑了几个可能具有病因学意义的因素。