Accelerated purine biosynthesis de novo in skin fibroblasts deficient in hypoxanthine--guanine phosphoribosyltransferase activity.

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作者信息

Rosenbloom F M, Henderson J F, Kelly W N, Seegmiller J E

出版信息

Biochim Biophys Acta. 1968 Aug 23;166(1):258-60. doi: 10.1016/0005-2787(68)90512-1.

DOI:10.1016/0005-2787(68)90512-1

PMID:5698059

Abstract

摘要

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Accelerated purine biosynthesis de novo in skin fibroblasts deficient in hypoxanthine--guanine phosphoribosyltransferase activity.

Biochim Biophys Acta. 1968 Aug 23;166(1):258-60. doi: 10.1016/0005-2787(68)90512-1.

Biochemical bases of accelerated purine biosynthesis de novo in human fibroblasts lacking hypoxanthine-guanine phosphoribosyltransferase.缺乏次黄嘌呤 - 鸟嘌呤磷酸核糖转移酶的人成纤维细胞中嘌呤从头合成加速的生化基础。

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Role of glutamine in purine synthesis and in guanine nucleotide formation in normal fibroblasts and in fibroblasts deficient in hypoxanthine phosphoribosyltransferase activity.

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Inhibitors of nucleoside and nucleotide metabolism.核苷和核苷酸代谢抑制剂。

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Mechanism of excessive purine biosynthesis in hypoxanthine-guanine phosphoribosyltransferase deficiency.次黄嘌呤-鸟嘌呤磷酸核糖转移酶缺乏症中嘌呤生物合成过多的机制。

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Mol Cell Biol. 1982 Dec;2(12):1619-27. doi: 10.1128/mcb.2.12.1619-1627.1982.

Hypoxanthine: guanine phosphoribosyltransferase mutants in Saccharomyces cerevisiae.酿酒酵母中的次黄嘌呤：鸟嘌呤磷酸核糖转移酶突变体

Mol Gen Genet. 1983;191(3):407-12. doi: 10.1007/BF00425755.

Hyperuricaemia: some biochemical aspects.高尿酸血症：一些生化方面

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Mechanism of excessive purine biosynthesis in hypoxanthine-guanine phosphoribosyltransferase deficiency.次黄嘌呤-鸟嘌呤磷酸核糖转移酶缺乏症中嘌呤生物合成过多的机制。

J Clin Invest. 1970 May;49(5):968-78. doi: 10.1172/JCI106316.

The substrate specificity of purine phosphoribosyltransferases in Schizosaccharomyces pombe.粟酒裂殖酵母中嘌呤磷酸核糖转移酶的底物特异性。

Biochem J. 1971 May;122(4):415-20. doi: 10.1042/bj1220415.

Characterization of a feedback-resistant phosphoribosylpyrophosphate synthetase from cultured, mutagenized hepatoma cells that overproduce purines.来自经诱变处理的培养肝癌细胞中一种对反馈抑制有抗性的磷酸核糖焦磷酸合成酶的特性鉴定，该肝癌细胞过量产生嘌呤。

Proc Natl Acad Sci U S A. 1973 Dec;70(12):3698-702. doi: 10.1073/pnas.70.12.3698.

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J Inherit Metab Dis. 1989;12(2):184-96. doi: 10.1007/BF01800725.

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