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羔羊在巅峰代谢和儿茶酚胺处理期间血浆葡萄糖、乳酸和游离脂肪酸的变化。

Changes in plasma glucose, lactate and free fatty acids in lambs during summit metabolism and treatment with catecholamines.

作者信息

Alexander G, Mills S C, Scott T W

出版信息

J Physiol. 1968 Sep;198(2):277-89. doi: 10.1113/jphysiol.1968.sp008606.

Abstract
  1. Exposure to cold increased the plasma levels of glucose and lactate in young lambs (< 1-63 days old). Free fatty acid concentrations also increased, the increase being much greater in lambs older than 20 days.2. Intravenous infusions of adrenaline and noradrenaline into lambs under a neutral thermal environment caused large increases in plasma glucose, lactate and free fatty acids.3. Adrenaline and noradrenaline infusions increased the concentration of palmitic, stearic and oleic acids in the plasma of young lambs.4. Treatment of lambs in summit metabolism with either alpha- or beta-adrenergic blocking agents (phentolamine or propranolol, respectively) caused the plasma levels of free fatty acids to fall. Phentolamine hydrochloride decreased the concentration of plasma glucose, but did not change the lactate level. In contrast, propranolol decreased the concentration of both of these metabolites in a significant proportion of the experiments.5. Induction of muscular paralysis by suxamethonium chloride, in lambs exposed to cold, resulted in a rise in plasma free fatty acids, and a fall in glucose and lactate levels.6. These observations suggest that the circulating level of plasma metabolites in young lambs is not the limiting factor in the metabolic response to cold exposure.
摘要
  1. 暴露于寒冷环境会使幼龄羔羊(1至63日龄)血浆中的葡萄糖和乳酸水平升高。游离脂肪酸浓度也会增加,20日龄以上的羔羊增加幅度更大。

  2. 在中性热环境下,向羔羊静脉注射肾上腺素和去甲肾上腺素会导致血浆葡萄糖、乳酸和游离脂肪酸大幅增加。

  3. 注射肾上腺素和去甲肾上腺素会使幼龄羔羊血浆中棕榈酸、硬脂酸和油酸的浓度增加。

  4. 用α-或β-肾上腺素能阻断剂(分别为酚妥拉明或普萘洛尔)处理处于最高代谢状态的羔羊,会导致血浆游离脂肪酸水平下降。盐酸酚妥拉明会降低血浆葡萄糖浓度,但不改变乳酸水平。相比之下,在相当一部分实验中,普萘洛尔会降低这两种代谢物的浓度。

  5. 在暴露于寒冷环境的羔羊中,氯化琥珀胆碱诱导肌肉麻痹会导致血浆游离脂肪酸升高,葡萄糖和乳酸水平下降。

  6. 这些观察结果表明,幼龄羔羊血浆代谢物的循环水平不是对寒冷暴露代谢反应的限制因素。

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