绵羊氨输注与肾上腺素输注代谢效应的比较。

Comparison of metabolic effect of ammonia and adrenaline infusions in sheep.

作者信息

Garwacki S, Wiechetek M, Barej W

出版信息

Q J Exp Physiol Cogn Med Sci. 1979 Jan;64(1):23-9. doi: 10.1113/expphysiol.1979.sp002455.

DOI:10.1113/expphysiol.1979.sp002455

Abstract

Intravenous infusions of ammonium chloride (62.3 mumol.kg-1.min-1) for 30 min caused a significant increase in blood glucose, lactate, pyruvate and free fatty acid (FFA) levels. A similar effect was also observed during infusion of adrenaline. Propanolol--a beta-receptor blocking agent--completely prevented the rise of blood pyruvate and lactate after adrenaline when 8.3 microgram.kg-1.min-1 of propranolol were infused, but not after NH4Cl administration. Lipolytic actions of adrenaline were completely prevented but that of NH4Cl was only significantly diminished by blockade of beta-receptors with propranolol. It was concluded that the influence of ammonium ions on blood lactate and pyruvate and FFA was not entirely mediated by adrenaline.

摘要

静脉输注氯化铵（62.3微摩尔·千克⁻¹·分钟⁻¹）30分钟可导致血糖、乳酸、丙酮酸和游离脂肪酸（FFA）水平显著升高。输注肾上腺素期间也观察到类似效应。当以8.3微克·千克⁻¹·分钟⁻¹的剂量输注普萘洛尔（一种β受体阻滞剂）时，可完全防止肾上腺素输注后血丙酮酸和乳酸的升高，但在给予氯化铵后则不能。普萘洛尔阻断β受体可完全防止肾上腺素的脂解作用，但仅显著减弱氯化铵的脂解作用。得出的结论是，铵离子对血乳酸、丙酮酸和游离脂肪酸的影响并非完全由肾上腺素介导。