循环儿茶酚胺对胎羊的代谢和内分泌影响。

The metabolic and endocrine effects of circulating catecholamines in fetal sheep.

作者信息

Jones C T, Ritchie J W

出版信息

J Physiol. 1978 Dec;285:395-408. doi: 10.1113/jphysiol.1978.sp012578.

DOI:10.1113/jphysiol.1978.sp012578

PMID:217988

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1281763/

Abstract

Adrenaline and noradrenaline have been infused into the fetal sheep to produce plasma concentrations comparable to those seen during hypoxia. The effects have been compared with those of isoprenaline and methoxamine and the sensitivity to beta- and alpha-adrenergic antagonists has been followed. 2. Adrenaline caused an alpha-mediated increase in blood glucose that is associated with a fall in plasma insulin concentration. It also caused a beta-mediated increase in plasma lactate, free fatty acid and amino acid concentrations. 3. Noradrenaline was much less effective than adrenaline at eliciting metabolic responses. It had not cause a significant change in plasma glucose concentration, although this was associated with a small increase in plasma insulin concentration. It caused a small rise in the concentration of lactate and free fatty acids in fetal plasma but had no effect on plasma amino acids. 4. The beta- and alpha-adrenergic antagonists propranolol and phentolamine alone were without effect on any of the plasma metabolites or hormones assayed. Isoprenaline increased plasma glucose, lactate, free fatty acid, alanine and insulin concentrations, while methoxamine only increased plasma glucose and lactate, and this was associated with a fall in insulin concentration. 5. The concentration of ACTH in fetal plasma was increased by adrenaline and to a lesser extent by noradrenaline and methoxamine; these were blocked by phentolamine. Isoprenaline also caused a small increase in ACTH. There were no corticosteroid changes associated with the increase in ACTH. 6. The results have been discussed in relation to the adrenergic and pancreatic control of metabolism in the fetal sheep.

摘要

已将肾上腺素和去甲肾上腺素注入胎羊体内，使其血浆浓度达到与缺氧时相当的水平。并将其效果与异丙肾上腺素和甲氧明的效果进行了比较，同时观察了对β-和α-肾上腺素能拮抗剂的敏感性变化。2. 肾上腺素引起α介导的血糖升高，这与血浆胰岛素浓度下降有关。它还引起β介导的血浆乳酸、游离脂肪酸和氨基酸浓度升高。3. 去甲肾上腺素引发代谢反应的效果远不如肾上腺素。它并未使血浆葡萄糖浓度发生显著变化，不过这与血浆胰岛素浓度略有升高有关。它使胎羊血浆中乳酸和游离脂肪酸浓度略有上升，但对血浆氨基酸无影响。4. 单独使用β-和α-肾上腺素能拮抗剂普萘洛尔和酚妥拉明对所检测的任何血浆代谢物或激素均无影响。异丙肾上腺素使血浆葡萄糖、乳酸、游离脂肪酸、丙氨酸和胰岛素浓度升高，而甲氧明仅使血浆葡萄糖和乳酸升高，且这与胰岛素浓度下降有关。5. 肾上腺素使胎羊血浆促肾上腺皮质激素（ACTH）浓度升高，去甲肾上腺素和甲氧明的作用较小；这些作用可被酚妥拉明阻断。异丙肾上腺素也使ACTH略有升高。ACTH升高并未伴随皮质类固醇的变化。6. 已结合胎羊代谢的肾上腺素能和胰腺控制对这些结果进行了讨论。