氯高铁血红素：一种红细胞核糖核酸酶抑制剂。
Hemin: an inhibitor of erythroid cell ribonuclease.
作者信息
Burka E R
出版信息
Science. 1968 Dec 13;162(3859):1287. doi: 10.1126/science.162.3859.1287.
PMID:5699205
Abstract
Hemin, in concentrations which stimulate protein synthesis and stabilize polyribosomes in reticulocytes, is a potent inhibitor of ribonuclease activity in the erythroid cell. This may offer a partial explanation for the way in which hemin acts to accelerate globin synthesis and thus synchronize the synthesis of hemin and globin in the maturing erythroid cell.
摘要
氯化血红素在能刺激网织红细胞中蛋白质合成并稳定多核糖体的浓度下，是红细胞中核糖核酸酶活性的有效抑制剂。这可能为氯化血红素加速珠蛋白合成从而使成熟红细胞中氯化血红素和珠蛋白的合成同步的作用方式提供部分解释。
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