Prado de Carvalho L, Izquierdo I
Arch Int Pharmacodyn Ther. 1978 Oct;235(2):280-8.
Increasing aqueous solutions of ethanol were given to rats, starting immediately after weaning, instead of drinking water. A 12% v/v concentration was reached on day 81 of age and maintained from then on. Animals drinking 12% ethanol had a median blood alcohol level of 333 mg/l. No major changes in their hippocampal or neocortical EEG patterns were observed at the age of 3 1/2 or 6--7 months while they were on the drug. Upon withdrawal, the younger group showed a decline of the mean frequency of hippocampal and neocortical large, irregular amplitude EEG activity; the older group showed instead a decline of the frequency of hippocampal theta. The performance of psuedoconditioned and of conditioned shuttle responses was unaltered after 3 1/2 to 6 months of ethanol consumption or after one week of abstinence from the drug.
从断奶后立即开始，用浓度不断增加的乙醇水溶液替代饮用水喂给大鼠。在81日龄时达到12%（体积/体积）的浓度，并从那时起保持该浓度。饮用12%乙醇的动物血液酒精水平中位数为333毫克/升。在3.5个月或6 - 7个月龄服用药物期间，未观察到它们的海马体或新皮质脑电图模式有重大变化。戒断后，较年轻的组海马体和新皮质大的、不规则振幅脑电图活动的平均频率下降；而较年长的组海马体θ波频率下降。在饮用乙醇3.5至6个月或停药一周后，伪条件反射和条件穿梭反应的表现未改变。
