Poldrugo F, Snead O C
Psychopharmacology (Berl). 1984;83(2):140-6. doi: 10.1007/BF00429722.
Rats chronically implanted with electrodes in the amygdala, thalamus, hippocampus, and cortex were addicted twice, separated by an interval of 2 weeks, with 18 days of ethanol liquid diet. The diet consumption and the blood ethanol levels (BELs) were carefully controlled twice a day during both addictive phases. After ethanol removal the behavioral and electroencephalographic (EEG) changes were continuously monitored for 24 h. During each withdrawal the behavioral and EEG changes appeared at the same time, the EEG changes being of shorter duration. Behavioral and EEG changes (primarily in hippocampus) were more severe and of earlier onset during the second withdrawal. In spite of an ethanol liquid diet intake comparable to that of the first addiction, during the ethanol readdiction the BELs were found to fluctuate. The results support the hypothesis of an ethanol withdrawal potentiation through a mechanism of kindling of different brain areas related to the observed BEL fluctuations.
对杏仁核、丘脑、海马体和皮层长期植入电极的大鼠进行两次成瘾实验，两次实验间隔2周，每次给予18天的乙醇液体饲料。在两个成瘾阶段，每天仔细控制两次饲料量和血液乙醇水平（BELs）。撤除乙醇后，连续24小时监测行为和脑电图（EEG）变化。每次戒断期间，行为和EEG变化同时出现，EEG变化持续时间较短。第二次戒断期间，行为和EEG变化（主要在海马体）更严重且发作更早。尽管第二次成瘾时乙醇液体饲料摄入量与第一次相当，但再次给予乙醇期间发现BELs波动。这些结果支持通过与观察到的BEL波动相关的不同脑区点燃机制来增强乙醇戒断反应的假说。
